An injectable multifunctional thermo-sensitive chitosan-based hydrogel for periodontitis therapy

Ma, Shiqing; Liu, Xuemei; Yu, Xiangyao; Du, Yaqi; Xu, Shendan; Li, Minting; Cheng, Peng; Liu, Zihao; Deng, Jiayin

doi:10.1016/j.bioadv.2022.213158

Cited by 17 publications

(13 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its primary characteristic is the capacity to introduce specific functional groups with reactive properties, yielding a range of chitosan derivatives via chemical modification. Chitosan-based hydrogel systems exhibit outstanding biocompatibility, degradability, anti-inflammatory effects, broad-spectrum antibacterial properties, as well as the ability to facilitate cell adhesion, proliferation, and differentiation ( Ma et al, 2022 ). Gu et al (2024) used forty-eight male Wistar rats to establish a periodontitis model to detect the effects of chitosan/β-sodium glyceropylate (β-GP)/glycolic acid (GA) hydrogel carrying erythropoietin and FK506 (EPO-FK506-CS/β-GP/GA).…”

Section: Classification Of Polymer-based Hydrogelsmentioning

confidence: 99%

“…Frontiers in Bioengineering and Biotechnology frontiersin.org ability to facilitate cell adhesion, proliferation, and differentiation (Ma et al, 2022). Gu et al (2024) used forty-eight male Wistar rats to establish a periodontitis model to detect the effects of chitosan/βsodium glyceropylate (β-GP)/glycolic acid (GA) hydrogel carrying erythropoietin and FK506 (EPO-FK506-CS/β-GP/GA).…”

Section: Natural Polymer-based Hydrogels 411 Chitosan-based Hydrogelmentioning

confidence: 99%

See 1 more Smart Citation

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.

show abstract

Section: Classification Of Polymer-based Hydrogelsmentioning

confidence: 99%

Section: Natural Polymer-based Hydrogels 411 Chitosan-based Hydrogelmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Additionally, as compared to the control group, there was a substantial enhancement in clinical parameters ( Gopalakrishna et al, 2023 ). CS thermo-responsive hydrogels loaded with antimicrobial peptides (Nal-P-113) and/or antioxidants (polydopamine nanoparticles, PDNPs) could act as a scavenger activity against DPPH was about 80% and perform antimicrobial activities against Staphylococcus gordonii , Fusobacterium nucleatum , and Porphyromonas gingivalis ( Ma et al, 2022 ).…”

Section: Treatment Of Periodontitis Via Employing ...mentioning

confidence: 99%

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

El-Nablaway,

Rashed,

Taher

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Periodontitis is an inflammation-related condition, caused by an infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production and eating, significantly diminish therapeutic medication residency in the region of periodontal disease. Furthermore, the complexity and diversity of pathological mechanisms make successful periodontitis treatment challenging. As a result, developing enhanced local drug delivery technologies and logical therapy procedures provides the foundation for effective periodontitis treatment. Being biocompatible, biodegradable, and easily administered to the periodontal tissues, hydrogels have sparked substantial an intense curiosity in the discipline of periodontal therapy. The primary objective of hydrogel research has changed in recent years to intelligent thermosensitive hydrogels, that involve local adjustable sol-gel transformations and regulate medication release in reaction to temperature, we present a thorough introduction to the creation and efficient construction of new intelligent thermosensitive hydrogels for periodontal regeneration. We also address cutting-edge smart hydrogel treatment options based on periodontitis pathophysiology. Furthermore, the problems and prospective study objectives are reviewed, with a focus on establishing effective hydrogel delivery methods and prospective clinical applications.

show abstract

“…As multi-component hydrogels with multifunctionality, injectable and thermo-sensitive chitosan hydrogels were combined with antimicrobial peptides (Nal-P-113) and polydopamine nanoparticles for periodontitis therapy. 115 The peptides and nanoparticles released from the hydrogels within 13 d. The antibacterial activity of Nal-P-113-containing hydrogel groups showed around 99% efficacy against Streptococcus gordonii , Fusobacterium nucleatum , and Porphyromonas gingivalis . Although the antimicrobial effect of chitosan is well-known, the impact of the peptides was mentioned prominently and presented in the results obtained during the antimicrobial activity measurements.…”

Section: Antimicrobial Hydrogels Developed For Periodonticsmentioning

confidence: 99%

Section: Hydrogels Containing Intrinsically Antimicrobial Peptides Fo...mentioning

confidence: 99%

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Atila,

Kumaravel

2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

An injectable multifunctional thermo-sensitive chitosan-based hydrogel for periodontitis therapy

Cited by 17 publications

References 53 publications

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Contact Info

Product

Resources

About