An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug

Özer, İmran; Slezak, Anna; Sirohi, Parul; Li, Xinghai; Zakharov, Nikita; Yao, Yunxin; Everitt, Jeffrey; Spasojević, Ivan; Craig, Stephen L.; Collier, Joel H.; Campbell, Jonathan E.; D’Alessio, David A.; Chilkoti, Ashutosh

doi:10.1016/j.biomaterials.2022.121985

Cited by 11 publications

(9 citation statements)

References 49 publications

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“…111 Another study that aimed to reduce the immunogenicity of PEG in a peptide conjugate context utilized poly[oligo(ethylene glycol)methyl ether methacrylate] (POEGMA). 112 POEGMA conjugated to exendin, a peptide drug used in the clinic to treat type 2 diabetes, displayed prolonged half-live in vivo upon subcutaneous administration and, importantly, did not elicit an immune response against the polymer. In contrast, repeated administration of the PEG-exendin conjugate mounted an antibody response against the PEG moiety, thus significantly reducing its efficacy long-term.…”

Section: Chemical Modifications To Proteins and Nucleic Acidsmentioning

confidence: 99%

Therapeutic synthetic and natural materials for immunoengineering

Slezak,

Chang,

Hossainy

et al. 2024

Chem. Soc. Rev.

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Section: Chemical Modifications To Proteins and Nucleic Acidsmentioning

confidence: 99%

Therapeutic synthetic and natural materials for immunoengineering

Slezak,

Chang,

Hossainy

et al. 2024

Chem. Soc. Rev.

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“…Therapeutic proteins and peptide drugs represent new frontiers of drug research and development, as they show better target affinity and safety than chemical drugs 74 , 220 . However, their clinical efficacy of them is often hindered by several drawbacks, including high plasma clearance rates, short circulation duration, instability, and side effects resulting from frequent administration 221 .…”

Section: Anti-inflammatory Nanotherapeuticsmentioning

confidence: 99%

“…Nevertheless, their review only focuses on the specific metal-based NPs for treating inflammatory diseases 71 . Moreover, numerous studies have shown promising results in nanotechnology-based diagnosis and treatment of inflammation in recent years 54 , 72 - 74 . Consequently, a systematic review is warranted to provide the latest developments in emerging nanotechnology-based approaches for diagnosing and managing chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Liu,

Lin,

Wang

et al. 2024

Theranostics

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Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases. Accurate detection and timely therapeutic intervention on inflammatory dysregulation are crucial for the effective therapy of inflammation-associated diseases. However, the clinical outcomes of inflammation-involved disorders are still unsatisfactory. Therefore, there is an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations with traditional therapeutics. Biomedical nanotechnology is one of the promising fields that can potentially transform the diagnosis and treatment of inflammation. In this review, we outline recent advances in biomedical nanotechnology for the diagnosis and treatment of inflammation, with special attention paid to nanosensors and nanoprobes for precise diagnosis of inflammation-related diseases, emerging anti-inflammatory nanotherapeutics, as well as nanotheranostics and combined anti-inflammatory applications. Moreover, the prospects and challenges for clinical translation of nanoprobes and anti-inflammatory nanomedicines are highlighted.

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“…The PEG hydrogel molecules have a simple structure and do not contain structural elements that are immunogenic to the organism, thus having low immunogenicity and not causing significant immune reactions. 30,31 The surface of the PEG hydrogels has anti-adhesive properties, effectively preventing the adhesion of biological molecules such as cells and proteins, thereby reducing the interference of the material with the organism. The PEG hydrogels have good biological similarity and are compatible with biological tissues, thus not causing significant foreign body reactions.…”

Section: Biomimetic Hydrogels For Organoid Culturesmentioning

confidence: 99%