An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction

Chen, Rui; Zhu, Chenlu; Liu, Xu; Gu, Yi; Ren, Shujing; Bai, Hua; Zhou, Qin; Liu, Xin; Shen, Lu; Bi, Xiaolin; Li, Weidong; Jia, Xiao‐Bin; Chen, Zhipeng

doi:10.1016/j.biomaterials.2021.120855

Cited by 68 publications

(63 citation statements)

References 32 publications

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“…The occurrence of VR is the result of the joint action of a variety of mechanisms (Table 2). In recent years, with the popularity of TCM, the advantages of TCM in the treatment of VR are more and more obvious (140). We do not comment on any monomer here, because the TCM formula consists of dozens of ingredients with numerous chemical molecules, making it difficult to elucidate the therapeutic mechanism of TCM (141)(142)(143)(144).…”

Section: Discussionmentioning

confidence: 99%

Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Zhu

Liang

2021

Front. Cardiovasc. Med.

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Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.

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Section: Discussionmentioning

confidence: 99%

Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Zhu

Liang

2021

Front. Cardiovasc. Med.

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“…Rui Chen prepared a novel self-healing elastin to mimic peptide hydrogel (EMH) [ 87 ]. Polydopamine (PDA) nanoparticles loaded with salvianolic acid B (SaB) can deliver SaB locally and enhance the self-healing ability of hydrogel.…”

Section: Application Of Self-healing Hydrogels In Tissue Engineeringmentioning

confidence: 99%

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Liang

Yuan

et al. 2022

Polymers

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Self-healing hydrogels and traditional hydrogels both have three-dimensional polymeric networks that are capable of absorbing and retaining a large amount of water. Self-healing hydrogels can heal and restore damage automatically, and they can avoid premature failure of hydrogels caused by mechanical damage after implantation. The formation mechanism of self-healing hydrogels and the factors that hydrogels can load are various. Researchers can design hydrogels to meet the needs of different tissues through the diversity of hydrogels Therefore, it is necessary to summarize different self-healing mechanisms and different factors to achieve different functions. Here, we briefly reviewed the hydrogels designed by researchers in recent years according to the self-healing mechanism of water coagulation. Then, the factors for different functions of self-healing hydrogels in different tissues were statistically analyzed. We hope our work can provide effective support for researchers in the design process of self-healing hydrogel.

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“…In addition, some studies have found that the new composite material obtained by the combination of solid scaffold materials and hydrogels not only has better mechanical properties but also shows some other unique properties such as self-healing [ 119 ]. Self-healing materials can repair themselves in a short time after being damaged, which can prevent the inhibitory effect of soft tissue infiltration on bone regeneration, thereby ultimately promoting bone damage repair [ 120 ]. Li et al [ 47 ] successfully prepared a self-healing material (CHA/SF/GCS/DF-PEG) with good mechanical properties and plasticity by using CHA as the main component of the bone graft material, combined with silk fibroin (SF), glycol chitosan (GCS) and difunctionalized polyethylene glycol (DF-PEG).…”

Section: Application Of Msc-evs In Bone Defectsmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair

et al. 2022

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The repair of critical bone defects is a hotspot of orthopedic research. With the development of bone tissue engineering (BTE), there is increasing evidence showing that the combined application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes, with hydrogels, scaffolds, and other bioactive materials has made great progress, exhibiting a good potential for bone regeneration. Recent studies have found that miRNAs, proteins, and other cargo loaded in EVs are key factors in promoting osteogenesis and angiogenesis. In BTE, the expression profile of the intrinsic cargo of EVs can be changed by modifying the gene expression of MSCs to obtain EVs with enhanced osteogenic activity and ultimately enhance the osteoinductive ability of bone graft materials. However, the current research on MSC-EVs for repairing bone defects is still in its infancy, and the underlying mechanism remains unclear. Therefore, in this review, the effect of bioactive materials such as hydrogels and scaffolds combined with MSC-EVs in repairing bone defects is summarized, and the mechanism of MSC-EVs promoting bone defect repair by delivering active molecules such as internal miRNAs is further elucidated, which provides a theoretical basis and reference for the clinical application of MSC-EVs in repairing bone defects.

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An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction

Cited by 68 publications

References 32 publications

Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Cellular and Molecular Mechanism of Traditional Chinese Medicine on Ventricular Remodeling

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair

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