An injectable thermosensitive photothermal-network hydrogel for near-infrared-triggered drug delivery and synergistic photothermal-chemotherapy

Liu, Chanjuan; Guo, Xiaolu; Ruan, Changping; Hu, Hailu; Jiang, Bang‐Ping; Liang, Hong; Shen, Xing‐Can

doi:10.1016/j.actbio.2019.07.024

Cited by 84 publications

(65 citation statements)

References 55 publications

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“…In another work, Liu et al. [ 89 ] reported on the fabrication of an IH via host–guest interaction between PEG and α ‐cyclodextrin to increase the photothermal performance, the retention time, and stability of photothermal agent, a thermosensitive photothermal network IH (PNT‐gel). The PEG chains grafted on the backbone of the conjugated polymer could effectively convert the irradiated NIR to light to induce the photothermal efficiency.…”

Section: Multiple Therapy Of Cancer By Ihsmentioning

confidence: 99%

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Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Poustchi

Amani

Ahmadian³

et al. 2020

Adv Healthcare Materials

118

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The complexity of hard-to-treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve the efficiency of available treatment options. The advantages of combination therapy include the possibility of synchronous alteration of different biological pathways, reducing the required effective therapeutic dose, reducing drug resistance, and lowering the overall costs of treatment. The tunable physical properties, excellent biocompatibility, facile preparation, and ease of administration with minimal invasiveness of injectable hydrogels (IHs) have made them excellent candidates to solve the clinical and pharmacological limitations of present systems for multitherapy by direct delivery of therapeutic payloads and improving therapeutic responses through the formation of depots containing drugs, genes, cells, or a combination of them in the body after a single injection. In this review, currently available methods for the design and fabrication of IHs are systematically discussed in the first section. Next, as a step toward establishing IHs for future multimodal synergistic therapies, recent advances in cancer combination therapy, wound healing, and tissue engineering are addressed in detail in the following sections. Finally, opportunities and challenges associated with IHs for multitherapy are listed and further discussed.

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Section: Multiple Therapy Of Cancer By Ihsmentioning

confidence: 99%

“…Moreover, the reversible gel–sol transition in this thermo‐sensitive IH with low critical solution transition (LCST), slightly above physiological temperature, could enhance the drug release in response to the NIR light, and as a result, an on‐demand drug release could be achieved. [ 89 ]…”

Section: Multiple Therapy Of Cancer By Ihsmentioning

confidence: 99%

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Poustchi

Amani

Ahmadian³

et al. 2020

Adv Healthcare Materials

118

View full text Add to dashboard Cite

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“…On the basis of the above results, it is concluded that the drug release behavior of ZIF-8/DMPP is pH-dependent and can be accelerated by NIR laser, which is conducive to combined chemo-photothermal therapy. 42…”

Section: Drug Release Of Zif-8/dmppmentioning

confidence: 99%

<p>Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy</p>

Guo

Xia

Feng

et al. 2020

IJN

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Background: Metal-organic frameworks (MOFs) have attracted intensive research interest in the biomedical field because of their unique properties. However, in order to realize the high loading capacity and therapeutic efficacy, it is still urgent to develop a multifunctional MOFs-based nanoplatform. Materials and Methods: Herein, a pH/near-infrared (NIR) dual-responsive drug delivery system based on zeolitic imidazolate framework-8 (ZIF-8) is constructed for synergistic chemo-photothermal therapy and dual-modal magnetic resonance (MR)/photoacoustic (PA) imaging. The doxorubicin hydrochloride (DOX) is embedded into ZIF-8 through one-pot method, and the resultant ZIF-8/DOX is then successively modified with polydopamine, Mn ions and poly(ethylene glycol). The obtained ZIF-8/DMPP is systematically characterized, and both its in vitro and in vivo biological effects are evaluated in detail. Results: The ZIF-8/DMPP possesses a high drug-loading content of 18.9% and displays appropriate size and morphology. The pH-dependent degradation and drug release behavior of prepared ZIF-8/DMPP are confirmed. Importantly, the results demonstrate that the photothermal effect of ZIF-8/DMPP under NIR laser irradiation can significantly accelerate its drug releasing rate, further improving the intracellular drug concentrations. Thereafter, the augmented chemotherapeutic efficiency by photothermal effect against cancer cells is verified both in vitro and in vivo. Besides, the favorable MR and PA imaging capacity of ZIF-8/ DMPP is also evidenced on the tumor model. Conclusion: Taken together, the surface engineering of ZIF-8-based nanocarrier in this work offers a promising strategy for the multifunctional MOFs-based drug delivery system.

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“…[10,11] The acidity of the extracellular and intracellular environments of tumors have been widely explored for the design of smart PNMs. [11,[35][36][37][38][39][40][41][42] pH-responsive PNMs are mainly engineered on the basis of variations of their NIR absorption, PET, surface charge, and size when in the bloodstream or normal tissue relative to the same parameters when in tumor tissue. Among the reported mechanisms for achieving a pH-activated change in the NIR absorption of a PNM, the pHinduced aggregation of the nanomaterial in the acidic TME is an effective approach.…”

Section: Ph-responsive Pnmsmentioning

confidence: 99%

“…[36] In addition to the aggregation of the nanomaterials, another strategy is to alter the energy levels of the photoactive nanomaterials by protonation and/or doping of pH-sensitive units on the PNMs in the acidic TME, which improves the photothermal conversion efficiency or ROS production. [9,12,[37][38][39][40][41] The physicochemical properties of small organic dye-based PNMs can vary based on pH. In these small, organic dye-based PNMs, the NIR absorption of the organic dye (e. g., cyanine dye and croconine) can be easily activated by protonation in an acidic TME.…”

Section: Ph-responsive Pnmsmentioning

confidence: 99%

Stimuli‐Responsive Nanomaterials for Smart Tumor‐Specific Phototherapeutics

et al. 2020

Self Cite

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Phototherapy, a type of photoresponsive regulation of biological activities, together with additional stimuli‐responsive features, offers significant potential for enhancing the precision and eﬃcacy of cancer treatments. To achieve tumor‐specific therapeutics, numerous studies have focused on the development of smart phototherapeutic nanomaterials (PNMs) that can respond to endogenous pathological characteristics (e. g., mild acidity, the overproduction of glutathione, the overproduction of hydrogen peroxide, the overexpression of specific surface receptors, etc.) present in the tumor and/or exogenous stimuli. Such responsiveness can effectively improve the physicochemical properties, cellular uptake, tumor‐targeting performance, and pharmacokinetic profile of PNMs. Herein, we will systematically discuss recent advances in this field. Moreover, potential challenges and future directions in the development of stimuli‐responsive PNMs are also presented to support the development of this emerging cutting‐edge research area.

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An injectable thermosensitive photothermal-network hydrogel for near-infrared-triggered drug delivery and synergistic photothermal-chemotherapy

Cited by 84 publications

References 55 publications

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

<p>Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy</p>

Stimuli‐Responsive Nanomaterials for Smart Tumor‐Specific Phototherapeutics

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