2009
DOI: 10.1128/mcb.00541-09
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An Innate Immunity Signaling Process Suppresses Macrophage ABCA1 Expression through IRAK-1-Mediated Downregulation of Retinoic Acid Receptor α and NFATc2

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Cited by 50 publications
(38 citation statements)
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“…Instead, we found evidence of TLR2/4-dependent reduction in the expression of cellular cholesterol efflux mediators, which is consistent with earlier reports that LPS has this effect 37,38) . Of greater interest, however, was the observation of TLR4-dependent upregulation of lipogenic gene expression, which, to our knowledge, has not been described previously.…”
Section: Role Of Tlr Signalling In Bacteria-induced Lipid Body Formationsupporting
confidence: 82%
“…Instead, we found evidence of TLR2/4-dependent reduction in the expression of cellular cholesterol efflux mediators, which is consistent with earlier reports that LPS has this effect 37,38) . Of greater interest, however, was the observation of TLR4-dependent upregulation of lipogenic gene expression, which, to our knowledge, has not been described previously.…”
Section: Role Of Tlr Signalling In Bacteria-induced Lipid Body Formationsupporting
confidence: 82%
“…Cells were harvested with PBS, resuspended in DMEM supplemented with 1% fetal bovine serum, and allowed to rest overnight before further treatment. As shown by our previous studies, BMDMs harvested through this approach possess relevant activities of macrophages (23)(24)(25).…”
Section: Methodsmentioning
confidence: 99%
“…At these concentrations, IL-2 increased ABCA1 gene expression and ABCA1 protein synthesis. The proximal promoter of mouse Abca1 gene contains NF of activated T cells binding sites cooperating with other sites to enhance the transcription of this gene (48). Because IL-2 activates NF of activated T cells (49), transcriptional regulation of ABCA1 by IL-2 is possible.…”
Section: Abcg1mentioning
confidence: 99%