2017
DOI: 10.1126/sciadv.1603078
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An innovative biologic system for photon-powered myocardium in the ischemic heart

Abstract: Solar-powered heart? Harnessing light to create myocardial renewable energy.

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Cited by 107 publications
(106 citation statements)
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References 28 publications
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“…The mass production and light‐controllable distribution of active Syne capable of photoautotrophy are unattainable by other conventional synthetic nanoparticles. Syne grow quickly and generate oxygen continuously under light but cannot grow and slowly fade without light, which effectively ensures the safety of their application, such as in cardiovascular disease treatment as reported previously . The smart HSA/ICG NP‐coated photosynthetic bacteria within S/HSA/ICG for treating cancer possess many unique advantages that are unachievable with conventional approaches.…”
Section: Resultsmentioning
confidence: 80%
See 1 more Smart Citation
“…The mass production and light‐controllable distribution of active Syne capable of photoautotrophy are unattainable by other conventional synthetic nanoparticles. Syne grow quickly and generate oxygen continuously under light but cannot grow and slowly fade without light, which effectively ensures the safety of their application, such as in cardiovascular disease treatment as reported previously . The smart HSA/ICG NP‐coated photosynthetic bacteria within S/HSA/ICG for treating cancer possess many unique advantages that are unachievable with conventional approaches.…”
Section: Resultsmentioning
confidence: 80%
“…Since then, substantial research has made use of the tumor‐targeting ability of bacteria to fabricate a specialized bacteria‐accumulated tumor artificial environment for targeted drug release or for the delivery of various functional nanoparticles to tumors for precise tumor inhibition . The photosynthetic bacteria capable of photoautotrophy with light‐controllable growth and photosynthesis, are of particular interest and have been applied to treat cardiovascular disease due to highly efficient oxygen generation . However, to date, no studies have used photosynthetic bacteria to treat tumors.…”
Section: Introductionmentioning
confidence: 99%
“…In Vivo Hemocompatibility : To test hemocompatibility, Wistar rats weighing ≈250–300 g were sedated, intubated, and underwent a left thoracotomy. Due to our lab's extensive experience with small and large animal IM cardiac injections, a maximum of 1–5% material leakage into the bloodstream was approximated. A typical IM cardiac injection in a rat is ≈100 µL.…”
Section: Methodsmentioning
confidence: 99%
“…Intriguingly, Joseph Woo and colleagues have recently reported that the photosynthesis process that happens in trees can be applied in the injured myocardium for oxygen supply [5]. They demonstrated that a bacterium Synechococcus elongatus, like the chloroplast in plants, could also photosynthesize after light exposure.…”
mentioning
confidence: 99%
“…In just 10 min, the oxygen level in the illuminated and nonilluminated parts of the heart increased by nearly 25-and three-fold, respectively. Importantly, light exposure on injected bacteria enhanced ventricular function during acute ischemia and exerted a far-reaching protective benefit in long-term ventricular performance [5]. The long-term functional benefit of such a photosynthetic therapy as a result of short-term light exposure (∼1-2 h) is surprising and amazing.…”
mentioning
confidence: 99%