2018
DOI: 10.1111/srt.12445
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An innovative method to quantitate tissue integration of hyaluronic acid‐based dermal fillers

Abstract: We developed a modified HE staining histological method and a new histomorphometric image analysis tool to quantitate biointegration of HA-based fillers in human skin. The results obtained in this study confirmed the known intermediate biointegration properties of Restylane®, thus validating these innovative methods.

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Cited by 9 publications
(11 citation statements)
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“…An objective assessment of the classification performance would require a precise comparison of the LDA images and HE staining at the pixel level. Such an investigation needs to develop histomorphometric tools of image analysis , including image registration algorithm, since spectral and histological images correspond to adjacent tissue sections.…”
Section: Resultsmentioning
confidence: 99%
“…An objective assessment of the classification performance would require a precise comparison of the LDA images and HE staining at the pixel level. Such an investigation needs to develop histomorphometric tools of image analysis , including image registration algorithm, since spectral and histological images correspond to adjacent tissue sections.…”
Section: Resultsmentioning
confidence: 99%
“…However, until now, a limited number of tissue integration studies examining in vivo filler distribution patterns have investigated only a small number of HA dermal filler products using a single injection route. 16–20 The present study compared the local tissue response and distribution pattern of 14 HA dermal fillers in mini pigs using two injection routes (intradermal and subcutaneous) equivalent to those intended for clinical use of the products. Similarities in the skin structure and vascularization network between humans and mini pigs allowed reliable prediction of morphological and cellular changes as well as histological behavior of the injected fillers in humans after injection.…”
Section: Discussionmentioning
confidence: 99%
“…Tissue integration was assessed by a pathologist who was guided by the evaluation criteria described elsewhere. 16 , 17 , 20 Briefly, the pathologist was given a description of the specific features that were considered to equate to either good tissue integration (homogeneity, even distribution across tissue section, and sufficient entanglement of filler within tissue fibers) or a lack of tissue integration (pooling, irregular distribution across tissue section, and minimal or no entanglement of filler within tissue fibers) which served as a guide for assessing this parameter.…”
Section: Methodsmentioning
confidence: 99%
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