An Innovative Solvent‐Responsive Coiling–Expanding Stent

Abstract

Coronary artery disease is the “first killer” in the world, while the classical treatment for this disease is to implant stent. An ideal vascular stent should be nontoxic with self‐expanding characteristics, quick expanding speed, and appropriate mechanical supporting property. However, no existing vascular stent covers all properties. Herein, a two‐way shape‐memory cellulose vascular stent, which can realize shape adjustments by mild solutions such as water and alcohol, is constructed. The shape‐memory characteristics, mechanical properties, cell toxicity, and biocompatibility, are systemically investigated by ex vivo experiment as well as molecule simulation and theoretical modeling, revealing that the achieved bilayer two‐way shape‐memory films (BSMFs) can be used as an artificial vascular stent. In particular, this vascular stent made from BSMFs shows superb biocompatibility according to live/dead cell viability assays. Ex vivo experiments reveal that the novel vascular stent can support arteria coronaria sinistra, or the left main coronary artery, at the opening state while the cross‐section of the vessel becomes two times larger than that of the initial state after implantation. Thus, it is believed that effective and scalable BSMFs can make meritorious fundamental contributions to biomaterials science and practical applications such as vascular stents.

Enhanced Shape Memory Metal-Coordinated Poly(aryl ether ketone)s with Tunable Gradient-Deformation Behaviors as well as Self-Healing and Reprocessing Abilities

“…Shape memory polymers (SMPs), as a classic kind of smart polymer materials, are able to memorize a temporary shape, perceive the external stimuli, and spontaneously recover to the original shape. − Generally, SMPs are composed of two phases: flexible regions and rigid regions, which together contribute to the programable manipulations of shape memory effect (SME). , Flexible regions, usually containing soft chains and amorphous phases, could be transformed upon external stimuli. In this stage, the temporary shape of SMPs could be obtained by the external force.…”

Lotus Leaf-Inspired Breathable Membrane with Structured Microbeads and Nanofibers

“…The quantum chemical calculations and deformation length ratios in different directions based on molecular dynamics simulation were studied and evaluated. Briefly, the PVDF droplet was first optimized by Geometry Optimization, and then the equilibrium geometries were built; last, the varying electric fields were applied by the Force field method in COMPASS . − The length deformation rations of droplets in the three-dimensional directions were calculated and analyzed.…”

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

“…At present, the main method for the treatment of coronary artery disease is to implant vascular stents and shape memory alloys into the dilated artery. Shi et al constructed a bi-directional shape memory cellulose scaffold which can be adjusted a by mild solution (such as water and alcohol), has excellent biocompatibility, and can support the left coronary artery or left main coronary artery in an open state [ 149 ].…”