An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

Aditi, Aditi; Mahajan, Nipun; Rawal, Shruti; Katare, Rajesh

doi:10.4172/2153-2435.1000273

Cited by 2 publications

(1 citation statement)

References 106 publications

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“…It is worthy to note that superoxide, hydroxyl, nitric oxide radicals, hydrogen peroxide and lipid peroxidation play a critical role in many other oxidative-stress related pathological conditions and diseases. Superoxide anion radical and other ROS species derived from it (hydrogen peroxide, hydroxyl radical) are responsible for myocardial tissue damage in ischemia/reperfusion injury; they are also involved in the pathogenesis of hypertension, chronic obstructive pulmonary disease, diabetic complications (coronary and peripheral artery diseases, diabetic retinopathy, nephropathy and neuropathy) [59,60]. Hydroxyl radical-induced DNA damage is involved in the initiation, promotion and progression of carcinogenesis [61].…”

Section: Resultsmentioning

confidence: 99%

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

et al. 2014

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Abstract:The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, the aim of this study was to screen the root extracts for their in vitro antioxidant activity and phenolic content. The roots were OPEN ACCESSMolecules 2014, 19 19115 extracted successively with chloroform, ethyl acetate, ethanol and water. The antioxidant activity of root extracts was evaluated in both cell-free and cell-based assays. Their chemical characterization was performed by Fourier transform infrared spectroscopy (FT-IR) whereas the total phenolic content was determined by the Folin-Ciocalteu method. The ethyl acetate extract displayed the highest phenolic content and was found to be the most active in the free radical scavenging and lipid peroxidation inhibition assays; it also showed a high antioxidant activity in MCF-12F cells. This study suggests a potential use of the ethyl acetate extract of Vernonia kotschyana not only as an antioxidant agent in gastroduodenal ulcers and gastritis, but also in other disorders characterized by high levels of oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

et al. 2014

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Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes

H¹,

Denden²,

Ghazouani³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.Reactive oxygen species metabolizing enzymes may play an important role in the prevention of type-2 diabetes (T2D) complications. We analyzed the association between Cu/Zn-SOD +35 A/C, Mn-SOD T47C, and CAT -21 A/T gene polymorphisms and complications, in combination with tea consumption in Tunisian T2D. A sample of 366 T2D subjects was enrolled in this study. All participants were asked about tea consumption and frequency. Anthropometric, clinical, and routine biochemical characteristics were obtained from subjects' updated medical records. Malondialdehyde, as an early marker of lipid peroxidation, was measured in plasma samples. Urinary polyphenol derivatives (UPDs), as a marker of polyphenols intake, were assessed by the Folin-Ciocalteu assay. SODs and CAT H. Abaidi et al. 8614©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 8613-8622 (2015) genotypes were determined by conventional restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) methods. From all subjects, the results showed that in high tea consumers (>3 cups/ day), the frequency of the Mn-SOD 47 CC genotype was significantly higher in T2D without complications compared with T2D with complications (P = 0.03; OR = 0.284; 95%CI = 0.086-0.939). However, no significant associations were observed with Cu/Zn-SOD +35 A/C or CAT -21 A/T genes polymorphisms. Additionally, the evaluation of UPDs showed that individuals carrying the Mn-SOD 47 CC genotype and consuming more than three cups of tea per day present significantly higher UPDs (P = 0.038). In conclusion, the Mn-SOD 47 C variant in combination with high tea consumption may provide protection against complications in T2D.

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An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

Cited by 2 publications

References 106 publications

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes

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