An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes

Abstract

As a continuation of our search for biologically active mushroom species the present study investigates in vitro antidiabetic properties of six edible and medicinal mushroom species: Agaricus blazei Murrill, Coprinus comatus (O.F.Müll.) Pers., Cordyceps militaris (L.) Fr., Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and Phellinus linteus Berk. & M.A. Curtis. In vitro assays on α-amylase and α-glucosidase enzyme inhibition were performed with methanolic extracts of the selected mushrooms. Furthermore, we calculated the necessary daily intake of mushroom extracts and dry mushroom powders based on the equivalent doses of therapeutic drug acarbose given to diabetic patients per day. Our comparative study on enzyme inhibition showed that the most promising potential is ascribed to I. obliquus extract, while no inhibition of α-amylase was recorded with M. conica and C. militaris methanolic extract at the tested concentration. This comparative study is the first highlighting in vitro antidiabetic potential by inhibition of α-amylase and α-glucosidase with methanolic extracts; which makes the investigated species more promising for the diabetes type-2 treatment by an additional and different mechanism of action.

Anti‐Inflammatory, Antioxidant and Enzyme Inhibition Activities in Correlation with Mycochemical Profile of Selected Indigenous Ganoderma spp. from Balkan Region (Serbia)

“…On the other hand, inhibition of carbohydrate digesting enzymes such as α‐amylase or α‐glucosidase have been earmarked as the main target to control postprandial glucose peak in type 2 diabetics patients [22,23] . In this respect, several inhibitors (tacrine and donepezil for Alzheimer's disease; acarbose and voglibose for type 2 diabetes) have been synthetically developed in an attempt to control the afore‐mentioned ailments.…”

Comparative investigation on edible mushroomsMacrolepiota mastoidea,M. rhacodesandM. procera: functional foods with diverse biological activities

“…2 It has been well demonstrated that wild mushrooms are one of the most important functional foods and good sources of nutraceuticals. 3,4 The fungi of the genus Macrolepiota belong to the family Agaricaceae (Basidiomycota). Besides the pleasant taste, Macrolepiota species are also known for their nutritional value.…”

Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats

“…Thus, the control of blood glucose level is a critical method to prevent the progression of type 2 diabetes and its complications (Martinez, Lockhart, Davies, Lindsay, & Dempster, ). In consideration of limitations and negative side effects of commercial chemosynthetic drugs, numerous scientific investigations are being incessantly conducted into various natural products, including triterpenoids (Khanra et al, ) and flavonoids (Tanveer, Akram, Farooq, Hayat, & Shafi, ), which have a preventive or therapeutic effect on diabetes (Stojkovic et al, ; Thompson & Davis, ). Therefore, dietary therapies targeting the origin of insulin resistance are preferable for the prevention of diabetes.…”