An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders

Bommaraju, Sumadhura; Dhokne, Mrunali D.; Arun, E.V.; Srinivasan, Krishnamoorthy; Sharma, Shyam Sunder; Datusalia, Ashok Kumar

doi:10.1016/j.pnpbp.2024.110943

Progress in Neuro-Psychopharmacology and Biological Psychiatry

2024

DOI: 10.1016/j.pnpbp.2024.110943

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An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders

Sumadhura Bommaraju,

Mrunali D. Dhokne,

E.V. Arun

et al.

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2024

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Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development

Habiba,

Choi,

Munni

et al. 2024

IJMS

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Foeniculum vulgare Mill, commonly known as fennel, is an aromatic herb traditionally used for culinary and medicinal purposes, with potential therapeutic effects on neurological disorders. However, limited research has focused on its neurotrophic impact, particularly on neuronal maturation and synaptic development. This study investigates the neurotrophic effects of F. vulgare ethanol extracts (FVSE) on the maturation of rat primary hippocampal neurons. Results show that FVSE and its prominent component, anethole, significantly promote neurite outgrowth in a dose-dependent manner. Optimal axonal and dendritic growth occurred at concentrations of 40 µg/mL FVSE and 20 µM anethole, respectively, without causing cytotoxicity, underscoring the safety of FVSE for neuronal health. Additionally, FVSE enhances the formation of synapses, essential for neuronal communication. Network pharmacology analysis revealed that FVSE components influence critical neurotrophic pathways, including PI3K-AKT and Alzheimer’s disease pathways. Specifically, FVSE modulates key proteins, including tropomyosin receptor kinase (Trk), glycogen synthase kinase 3 (GSK3βser9), phosphatidylinositol 3-kinase (PI3K), and extracellular signal-regulated protein kinase (Erk1/2). Anethole was found to play a key role in regulating these pathways, which was confirmed by immunocytochemistry experiments demonstrating its effect on promoting neuronal growth and synaptic development. In conclusion, this study highlights the neurotrophic properties of FVSE, with anethole emerging as a critical bioactive compound. These findings provide valuable insights into the therapeutic potential of fennel in treating neurological disorders, offering a basis for future research into interventions promoting neuronal growth and survival.

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Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development

Habiba,

Choi,

Munni

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders

Cited by 1 publication

References 259 publications

Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development

Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development

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