An insight into molecularly imprinted polymers for capillary electrochromatography

Liu, Chuen‐Ying; Lin, Chun‐Chi

doi:10.1002/elps.200406160

Cited by 39 publications

(21 citation statements)

References 119 publications

(104 reference statements)

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“…Apart from HPLC MIPs have also been used as media for Capillary Electrochromatography (CEC) [39,62]. In fact, the high efficiency of CEC may potentially overcome the mass transfer and kinetic limitations of MIP-based liquid chromatography by the rectangular plug flow profile in the CEC.…”

Section: Mips As Chromatographic Mediamentioning

confidence: 99%

Molecularly imprinted polymers and their application in solid phase extraction

Lasáková

Jandera

2009

J of Separation Science

130

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Solid phase extraction is routinely used in many different areas of analytical chemistry. Some of the main fields are environmental, biological, and food chemistry, where cleaning and pre-concentration of the sample are important steps in the analytical protocol. Molecularly imprinted polymers (MIPs) have attracted attention because they show promise as compound-selective or group-selective media. The application of these synthetic polymers as sorbents allows not only pre-concentration and cleaning of the sample but also selective extraction of the target analyte, which is important, particularly when the sample is complex and impurities can interfere with quantification. This review surveys the selectivity of MIPs in solid phase extraction of various kinds of analytes.

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Section: Mips As Chromatographic Mediamentioning

confidence: 99%

Molecularly imprinted polymers and their application in solid phase extraction

Lasáková

Jandera

2009

J of Separation Science

130

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“…The recognition properties of MIPs have been explored via high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC), the majority of application being with CEC recently as revealed in recent reviews. [13][14][15][16][17][18][19][20] CEC makes use of both superior selectivity of HPLC and high separation efficiency of capillary electrophoresis (CE). Among the various formats used in CEC, open-tubular capillary electrochromatography (OT-CEC)-based MIP columns are promising tools for the research of recognition abilities of MIPs owing to the merits such as simple column preparation, no bubble formation, and stable EOF application, etc.…”

Section: 12mentioning

confidence: 99%

Open Tubular Molecular Imprinted Polymer Fabricated in Silica Capillary for the Chiral Recognition of Neutral Enantiomers in Capillary Electrochromatography

Yang¹,

Zaidi²,

Cheong³

et al. 2012

Bulletin of the Korean Chemical Society

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In this study, we have expanded the applicability of the pre-established generalized preparation protocol to MIPs with a neutral template. The (4S,5R)-4-methyl-5-phenyl-2-oxazolidinone MIP layer was formed inside a pretreated and silanized fused silica capillary, and its chiral separation performance was examined. Optimization of chiral separation was also carried out. This is the very first report of somewhat successful application of the generalized preparation protocol to a MIP with a genuine neutral template.

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“…The molecule imprinted polymer (MIP) has emerged as a successful technique for a variety of application, and MIP recognition ability has been investigated mostly by liquid chromatography (LC) and capillary electrochromatography (CEC) [5][6][7][8]. Coupling the MIP technique to CEC has proven to be promising owing to prominent selectivity of MIP and high efficiency of CEC [9][10][11]. Especially, OT-MIP approach in CEC has assured further improved performance of this approach in separation science [12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 98%

Examination of Template Structural Effects on CEC Chiral Separation Performance of Molecule Imprinted Polymers Made by a Generalized Preparation Protocol

et al. 2011

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Some acidic chiral templates were used to prepare open tubular (OT) molecule imprinted polymer (MIP) capillary columns to explore the effects of molecular structures of templates on chiral recognition capabilities and to verify the feasibility of the general MIP preparation protocol introduced in the previous study. The templates are phenyl carboxylic acids and their derivatives. Optimization was carried out for chiral separation of template enantiomers for each MIP column through varying pH and composition of eluent. It was found that the preparation protocol can be successfully applied for the appropriate templates with functional groups fulfilling the three-points interaction rule. The chiral separation performances were quite satisfactory for MIPs of such templates although they are yet inferior to the separation performances of the MIP columns fabricated with the templates of profen drugs (2-arylpropionic acids with a large substituent on the phenyl ring). Subtle variations of the template molecular structures have been found to be critical to enhance chiral recognition ability of the resultant MIP column.

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An insight into molecularly imprinted polymers for capillary electrochromatography

Cited by 39 publications

References 119 publications

Molecularly imprinted polymers and their application in solid phase extraction

Molecularly imprinted polymers and their application in solid phase extraction

Open Tubular Molecular Imprinted Polymer Fabricated in Silica Capillary for the Chiral Recognition of Neutral Enantiomers in Capillary Electrochromatography

Examination of Template Structural Effects on CEC Chiral Separation Performance of Molecule Imprinted Polymers Made by a Generalized Preparation Protocol

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