An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity

Abstract

Depression and anxiety are widespread illnesses whose consequences on patients' social and professional lives are becoming ever more dangerous and severe. The study's objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its antioxidant power as they were recently associated. The predictive antidepressant activity was evaluated using the forced swimming and tail suspension test in mice, a preclinical behavioral model widely used to determine the efficacy of antidepressant drugs. As for anxiolytic-like activity, two models were used, namely the light/dark chamber test to measure the animal's degree of anxiety and the open field test to evaluate both anxiolytic and locomotor activity. The tests results indicate a remarkable antidepressant and anxiolytic-like effect after oral administration of the polyphenolic fraction of C. carvi and interesting antioxidant property. In the extract it has been confirmed the presence of 6 molecules belonging to polyphenols, identified with HPLC analysis. This study confirms and encourages the traditional use of the extract and appeals to further studies to understand its action mechanism.

Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice

“…Likewise, the number of tiles traversed during the open-field test increased significantly at the lowest dose used in this study. These results are in accordance with other studies using OFT to investigate the anxiolysis effect of plants and other drugs [26].…”

“…Clinical and pre-clinical trials have reported successful use of medications for certain plant metabolites, such as alkaloids, terpenes, flavonoids, and sterols and others [ 24 , 25 ]. Medicinal plants have also proven efficacy against depression and anxiety, reported with the use of multiple plants, such as Carum carvi polyphenols at doses of 50 and 100 mg/kg [ 26 ], Coriandrum sativum at doses of 50, 100, and 200 mg/kg [ 27 ], Origanum majorana polyphenols at doses of 50 and 100 mg/kg [ 28 ], and Petroselinum sativum at doses of 50 and 100 mg/kg [ 29 ].…”

“…In view of these findings, this plant presents a potent potential that could be well established as a completely safe alternative to conventional drugs or to be recommended as a complement. The FST (Figure 9), by [58], was used as described in [26]. Mice were placed singly and forced to swim in a rectangular pool with the following dimensions (50 × 30 × 60), filled with water to 25 cm, maintained at 28-29 • C. The test is based on the idea that the animal would deliberately swim to avoid stressful stimulation.…”

“…The FST ( Figure 9 ), by [ 58 ], was used as described in [ 26 ]. Mice were placed singly and forced to swim in a rectangular pool with the following dimensions (50 × 30 × 60), filled with water to 25 cm, maintained at 28–29 °C.…”

The Effect of Young Leaves Extract of Arumanis Mango as an Antidepressant in Zebrafish (Danio rerio)

“…Peran antioksidan sebagai antidepresan mengacu pada salah satu fungsinya dalam mencegah reaksi oksidasi, termasuk stres oksidatif (Es-safi et al, 2021). Aktivitas antioksidan pada ekstrak pucuk mangga yang sangat kuat, menjadikan ektrak ini berpotensi dangat baik dalam mekanisme pemulihan tubuh dari stres sebagai produk antidepresan alternatif.…”