An Insight Into the Pathogenesis of Optic Disc Pit–Associated Maculopathy With Enhanced Depth Imaging

Gowdar, Jaitra P.; Rajesh, Bindu; Anantharaman, Giridhar; Gopalakrishnan, Mahesh; Hussain, Rameez; Thachil, Thomas

doi:10.1001/jamaophthalmol.2014.6093

Cited by 32 publications

(19 citation statements)

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“…Accumulation of macular fluid due to transudate from poorly developed peri-papillary choroidal vasculature, liquefied vitreous, and CSF have all been reported as putative sources of macular fluid. 3 Several reports using enhanced depth imaging have demonstrated a track extending from the peripapillary retina to cystic cavities posterior to the lamina cribrosa, providing indirect support forCSF, 2,3 but no such connection has been confirmed histologically or after subarachnoid injection of india ink in a dog model. 6 …”

Section: Discussionmentioning

confidence: 99%

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Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

et al. 2016

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Section: Discussionmentioning

confidence: 99%

“…1–3 Reports using enhanced depth imaging have demonstrated a track communicating from cavities posterior to the lamina cribrosa to the peripapillary retina, and these cavities presumably consist of cerebrospinal fluid (CSF). 2,3 …”

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confidence: 99%

Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

et al. 2016

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“…In fact, there are frequent retinoschisislike separations of the retina during the development of the serous macular detachments in eyes associated with congenital ODP. [8][9][10][11] We report two familiar cases of bilateral ODP associated with macular schisis and serous detachment.…”

Section: Introductionmentioning

confidence: 96%

Intrafamilial heterogeneity of congenital optic disc pit maculopathy

Rossi

Rosa

D'Alterio

et al. 2016

Ophthalmic Genetics

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The findings of our familial cases support the hypothesis that optic disc pit associated with maculopathy could be a genetic disease with an autosomal dominant inheritance pattern. Optical coherence tomography is the most helpful diagnostic tool to assess maculopathy associated with optic disc pit. Microperimetry and multifocal-electroretinography are useful for the diagnosis of macular dysfunction in the early stages, and for the prognosis and follow-up of optic disc pit-maculopathy which is the main cause of visual impairment in these patients. Furthermore, in consideration of the variable expressivity and disease severity reported in our cases, genetic anticipation may be hypothesized.

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“…Optic disc pits (ODPs) are considered to be part of a spectrum of rare congenital cavitary anomalies of the optic disc, which also include optic disc coloboma, morning glory disc anomaly and extrapapillary cavitation [1]. They are rare clinical entities, the majority occurring on the temporal side of the optic disc, and their prevalence is estimated to be 1 in 10,000 among the population.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Internal Limiting Membrane Flap Techniques with Vitrectomy for Macular Detachment Associated with an Optic Disc Pit

et al. 2019

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Purpose: To compare the anatomical and functional outcome of adjuvant pars plana vitrectomy (PPV) procedures using the techniques of translocation of an internal limiting membrane (ILM) flap and transplantation of an inverted ILM flap for the treatment of chronic and/or refractory optic disc pit (ODP) maculopathy. Methods: In this prospective interventional case series study, 9 patients (9 eyes) with chronic and/or refractory ODP maculopathy underwent PPV with either translocation of an ILM flap or transplantation of an inverted ILM flap as adjuvant techniques along with gas tamponade. The anatomical success, rates of macular reattachment, and visual improvement were assessed. Results: The mean preoperative central retinal thickness (CRT) was 723.4 µm (range: 366–1,151). The mean postoperative CRT was 398.1 ± 212.2 µm (range: 210–758). An increased preoperative CRT was associated with a lower chance of postoperative reattachment of the macula (p = 0.047). The overall reattachment rate at the end of the follow-up period was 56% (n = 5). The mean preoperative visual acuity (logMAR unit [Snellen acuity]) was 0.48 (20/60) (range: 1.30 [20/400] to 0.10 [20/25]). The mean change in best corrected visual acuity (BCVA) was 0.48 ± 0.233 logMAR units (approx. 3 lines of visual improvement). Conclusions: ILM flap techniques are logical and straightforward approaches as adjuvants to PPV treatment of ODP maculopathy. They could be viable adjuvant treatments for improvement in BCVA and CRT in patients with ODP maculopathy.

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An Insight Into the Pathogenesis of Optic Disc Pit–Associated Maculopathy With Enhanced Depth Imaging

Abstract: hyporeflective tract is seen connecting the ILRS and the cavity within the optic disc pit (Figure 2D).

Cited by 32 publications

References 13 publications

Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

Intrafamilial heterogeneity of congenital optic disc pit maculopathy

Efficacy of Internal Limiting Membrane Flap Techniques with Vitrectomy for Macular Detachment Associated with an Optic Disc Pit

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