An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli

Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphyrins: Photo-Antiproliferative Activity Evaluation towards T24 Human Bladder Cancer Cells

“…TMPyP was synthesized following previously described literature [28][29][30]. The neutral precursor 5,10,15,20-tetra(4-pyridyl)porphyrin (TPyP) was synthesized through the reaction of 4-pyridinecarboxaldehyde (5.5 mL, 58 mmol) with pyrrole (4.0 mL, 58 mmol) in refluxing acetic acid (120 mL) and nitrobenzene (70 mL) for 1 h at 120 • C. The solvents were distilled under reduced pressure.…”

The Role of Porphyrinoid Photosensitizers for Skin Wound Healing

“…The strong absorption usually exhibited by these highly conjugated aromatic compounds in the visible region (Figure 2A) and their ability to generate reactive oxygen species (ROS), such as oxygen singlet ( 1 O2), under light irradiation and in the presence of dioxygen (Figure 2B) are particularly relevant for their success to mediate the photodynamic process in photodynamic therapy (PDT) against tumoral cells [33,36,41,42], but also toward non-oncological pathologies, such as age-related macular degeneration. In the last two decades, porphyrinoids (either as free-base or coordinated with different metals) have been recognized as highly efficient PS to eradicate a broad range of microorganisms including drug-resistant strains using the same concept of PDT [31,37,[43][44][45][46][47][48][49][50].…”

“…The strong absorption usually exhibited by these highly conjugated aromatic compounds in the visible region (Figure 2A) and their ability to generate reactive oxygen species (ROS), such as oxygen singlet ( 1 O 2 ), under light irradiation and in the presence of dioxygen (Figure 2B) are particularly relevant for their success to mediate the photodynamic process in photodynamic therapy (PDT) against tumoral cells [33,36,41,42], but also toward non-oncological pathologies, such as age-related macular degeneration. In the last two decades, porphyrinoids (either as free-base or coordinated with different metals) have been recognized as highly efficient PS to eradicate a broad range of microorganisms including drug-resistant strains using the same concept of PDT [31,37,[43][44][45][46][47][48][49][50]. The strong absorption usually exhibited by these highly conjugated aromatic compounds in the visible region (Figure 2A) and their ability to generate reactive oxygen species (ROS), such as oxygen singlet ( 1 O2), under light irradiation and in the presence of dioxygen (Figure 2B) are particularly relevant for their success to mediate the photodynamic process in photodynamic therapy (PDT) against tumoral cells [33,36,41,42], but also toward non-oncological pathologies, such as age-related macular degeneration.…”

Photophysical and Bactericidal Properties of Pyridinium and Imidazolium Porphyrins for Photodynamic Antimicrobial Chemotherapy

“…As their efficacy is partially due to their quaternary ammonium functions [ 17 ], porphyrins carrying imidazole groups (or N -methyl derivatives) should also show interesting properties. Moreover, even if imidazole (metallo)porphyrins have been studied for their conductivity properties [ 30 , 31 , 32 ] or their antioxidant potencies [ 33 ], their photocytotoxicity has rarely been spotlighted [ 34 , 35 ], especially in PACT as A 4 or A 3 B structures [ 36 , 37 , 38 ]. In the same way, phenylimidazole porphyrins have also been presented in few reports, but never as A 4 porphyrins [ 39 ].…”