An Insight on the Role of Altered Function and Expression of Exosomes and MicroRNAs in Female Reproductive Diseases

Javadi, Maryam; Rad, Jafar Soleimani; Farashah, Mohammad Sadegh Gholami; Roshangar, Leila

doi:10.1007/s43032-021-00556-9

Cited by 22 publications

(17 citation statements)

References 127 publications

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“…Evaluation of these miRNAs in patients with endometriosis has shown that more than 200 are differentially expressed in patients with and without endometriosis [ 8 , 9 , 10 ] with some literature on their relevance in endometriosis’ diagnostic [ 11 , 12 , 13 ]. Among these 200 miRNAs, only a few have been analyzed with a view to better understanding the pathophysiology of endometriosis [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Plasma Micro-RNA Expression

Dabi

Suisse²,

Jornéa

et al. 2022

Diagnostics

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The pathophysiology of endometriosis remains poorly understood. The aim of the present study was to investigate functions and pathways associated with the various miRNAs differentially expressed in patients with endometriosis. Plasma samples of the 200 patients from the prospective “ENDO-miRNA” study were analyzed and all known human miRNAs were sequenced. For each miRNA, sensitivity, specificity, and ROC AUC values were calculated for the diagnosis of endometriosis. miRNAs with an AUC ≥ 0.6 were selected for further analysis. A comprehensive review of recent articles from the PubMed, Clinical Trials.gov, Cochrane Library, and Web of Science databases was performed to identify functions and pathways associated with the selected miRNAs. In total, 2633 miRNAs were found in the patients with endometriosis. Among the 57 miRNAs with an AUC ≥ 0.6: 20 had never been reported before; one (miR-124-3p) had previously been observed in endometriosis; and the remaining 36 had been reported in benign and malignant disorders. miR-124-3p is involved in ectopic endometrial cell proliferation and invasion and plays a role in the following pathways: mTOR, STAT3, PI3K/Akt, NF-κB, ERK, PLGF-ROS, FGF2-FGFR, MAPK, GSK3B/β–catenin. Most of the remaining 36 miRNAs are involved in carcinogenesis through cell proliferation, apoptosis, and invasion. The three main pathways involved are Wnt/β–catenin, PI3K/Akt, and NF–KB. Our results provide evidence of the relation between the miRNA profiles of patients with endometriosis and various signaling pathways implicated in its pathophysiology.

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Section: Introductionmentioning

confidence: 99%

Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Plasma Micro-RNA Expression

Dabi

Suisse²,

Jornéa

et al. 2022

Diagnostics

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“…[ 6 ] Moreover, exosomes are enriched with mRNAs, miRNAs, and proteins derived from the original cells. [ 7 ] Therefore, they are grafted with the native biological functions of their parental cells. For example, M2 macrophages play an inhibitory role in many inflammatory diseases including SCI.…”

Section: Introductionmentioning

confidence: 99%

Engineering of M2 Macrophages‐Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair

Zeng

Sun

et al. 2023

Adv Healthcare Materials

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Spinal cord injury (SCI) is one of the most common causes of death and disability. The effective modulation of complicated microenvironment, regeneration of injured spinal cord tissue, and the functional recovery after SCI are still clinical challenges. Recently, macrophages‐derived exosomes have shown great potential for various diseases due to their inflammation‐targeting property. However, further modifications are needed to endow exosomes with the neural regenerative potential for SCI recovery. In the current study, a novel nanoagent (MEXI) is designed for SCI treatment by conjugating bioactive IKVAV peptides to the surface of M2 macrophages‐derived exosomes via an easy and rapid click chemistry method. In vitro, MEXI inhibits the inflammation by reprograming macrophages and promotes neuronal differentiation of neural stem cells. In vivo, engineered exosomes target the injured site of the spinal cord after tail vein injection. Furthermore, histological analysis reveals that MEXI improves motor functional recovery of SCI mice by reducing infiltration of macrophages, downregulating pro‐inflammatory factors, and improving the regeneration of injured nervous tissues. Taken together, this study provides strong evidence for the significance of MEXI in SCI recovery.

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“…Several studies from the last two decades have demonstrated a clear influence of altered miRNA expression on the development of various diseases, including some neurological and autoimmune disorders [ 12 , 13 , 14 ]; congenital heart diseases such as tetralogy of Fallot [ 15 ]; and female reproductive diseases, such as preeclampsia, uterine leiomyomas, endometriosis and polycystic ovary syndrome (PCOS) [ 16 ]. Although PCOS manifests itself clinically in a very heterogeneous way, three symptoms predominate increased androgen production, ovulation disorders and ultrasound findings of polycystic ovaries [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review

et al. 2022

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MicroRNAs (miRNAs) are small, non-coding RNAs that are essential for the regulation of post-transcriptional gene expression during tissue development and differentiation. They are involved in the regulation of manifold metabolic and hormonal processes and, within the female reproductive tract, in oocyte maturation and folliculogenesis. Altered miRNA levels have been observed in oncological and inflammatory diseases, diabetes or polycystic ovary syndrome (PCOS). Therefore, miRNAs are proving to be promising potential biomarkers. In women with PCOS, circulating miRNAs can be obtained from whole blood, serum, plasma, urine, and follicular fluid. Our systematic review summarizes data from 2010–2021 on miRNA expression in granulosa and theca cells; the relationship between miRNAs, hormonal changes, glucose and lipid metabolism in women with PCOS; and the potential role of altered miRNAs in fertility (oocyte quality) in PCOS. Furthermore, we discuss miRNAs as a potential therapeutic target in PCOS and as a diagnostic marker for PCOS.

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An Insight on the Role of Altered Function and Expression of Exosomes and MicroRNAs in Female Reproductive Diseases

Cited by 22 publications

References 127 publications

Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Plasma Micro-RNA Expression

Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Plasma Micro-RNA Expression

Engineering of M2 Macrophages‐Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair

The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review

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