With the rapid development of new energy in China, the large-scale grid connection of new energy continues to rise, and the operation safety of new energy power systems is facing a severe test. Therefore, correct identification and assessment of security risks become an important prerequisite to effectively improve the operation safety level of the new energy power systems. In order to accurately and effectively complete the security and stability assessment of the new energy power system operation, a new energy power system operation security assessment model based on the fuzzy DEMATEL-AEW cloud model was built. Firstly, the paper collects the index set that affects the safe and stable operation of the new energy power system, and selects 15 indexes that have a great impact on the safe and stable operation of the system through the association rules mining algorithm (Apriori), and establishes the evaluation index system for the safe and stable operation of the new energy power system. Then, the fuzzy decision-making laboratory analysis method (DEMATEL) is used to determine the interaction between the evaluation indicators, draw the network structure diagram between the evaluation indicators, and determine the subjective weight of each evaluation indicator. The objective weight of each evaluation index is determined by using the anti-entropy weight (AEW) method, and the comprehensive weight of the evaluation index is calculated by using the dynamic weighting of cooperative game theory; Finally, the weight results are combined with the evaluation layer of cloud model to evaluate the safety of all levels of safety assessment indicators, and the simulation analysis of the example is completed through MATLAB. The results show that the operation security status level of the power system is between average and good, not only taken some effective measures to control some risk factors, but also normal inspection and monitoring are arranged; At the same time, carried out the comparative analysis of the simulation results in the security assessment of power system operation to verify the feasibility and accuracy of evaluation methods, and has guiding significance for the security assessment of power system.