An integrated micro-extracting system facilitates lesion-free biomacromolecules enrichment and detection

Mo, Xiaoyi; Wen, Zhenxing; Mo, Jingshan; Liu, Fanmao; Chen, Meiwan; Zhan, Changyuan; Zhang, Meng; Wang, Ji; Wen, Shifeng; Xie, Xi; Chen, Hui‐Jiuan; Chen, Bailing

doi:10.1016/j.matdes.2022.110812

Materials & Design

2022

DOI: 10.1016/j.matdes.2022.110812

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An integrated micro-extracting system facilitates lesion-free biomacromolecules enrichment and detection

Xiaoyi Mo

Zhenxing Wen²,

Jingshan Mo³

et al.

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2024

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Cited by 3 publications

References 45 publications

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An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect

Mo,

Meng,

et al. 2024

Small Methods

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Human parathyroid hormone (1–34) (PTH) exhibits osteoanabolic and osteocatabolic effects, with shorter plasma exposure times favoring bone formation. Subcutaneous injection (SCI) is the conventional delivery route for PTH but faces low delivery efficiency due to limited passive diffusion and the obstruction of the vascular endothelial barrier, leading to prolonged drug exposure times and reduced osteoanabolic effects. In this work, a microcurrent delivery system (MDS) based on multimicrochannel microneedle arrays (MMAs) is proposed, achieving high efficiency and safety for PTH transdermal delivery. The internal microchannels of the MMAs are fabricated using high‐precision 3D printing technology, providing a concentrated and safe electric field that not only accelerates the movement of PTH but also reversibly increases vascular endothelial permeability by regulating the actin cytoskeleton and interendothelial junctions through Ca2+‐dependent cAMP signaling, ultimately promoting PTH absorption and shortening exposure times. The MDS enhances the osteoanabolic effect of PTH in an osteoporosis model by inhibiting osteoclast differentiation on the bone surface compared to SCI. Moreover, histopathological analysis of the skin and organs demonstrated the good safety of PTH delivered by MDS in vivo. In addition to PTH, the MDS shows broad prospects for the high‐efficiency transdermal delivery of macromolecular drugs.

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An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect

Mo,

Meng,

et al. 2024

Small Methods

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Application of microneedle arrays in cosmetics: Promises, advances, and challenges

Rajput,

Patil,

Kandhare

et al. 2024

Medicine in Novel Technology and Devices

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Emerging innovations in portable chemical sensing devices: Advancements from microneedles to hydrogel, microfluidic, and paper-based platforms

Wang,

Zhou,

Niu

et al. 2024

Talanta

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An integrated micro-extracting system facilitates lesion-free biomacromolecules enrichment and detection

Cited by 3 publications

References 45 publications

An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect

An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect

Application of microneedle arrays in cosmetics: Promises, advances, and challenges

Emerging innovations in portable chemical sensing devices: Advancements from microneedles to hydrogel, microfluidic, and paper-based platforms

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