An integrative review on bioactive compounds from Indian mangroves for future drug discovery

Parthiban, A.; Sivasankar, R.; Sachithanandam, V.; Khan, Shagufta; Annamalai, Jayshree; Murugan, K; Sridhar, R.

doi:10.1016/j.sajb.2021.10.004

Cited by 14 publications

(8 citation statements)

References 79 publications

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“…The administration of the mangrove fruit extract to animal models presents multiple vantages such as antioxidant [ 56 ], anti-atherosclerosis [ 57 ], antimicrobial [ 47 , 58 ], anti-diabetes [ 59 ], and hepatoprotective properties [ 60 ]. Excessive free-radical levels of diabetes trigger other diseases due to oxidative stress.…”

Section: Nutrition Composition and Bioactivity Of Mangrove Fruit Extractmentioning

confidence: 99%

“…Mangrove fruit is a source of bioactive compounds with antioxidant activities. The antioxidant activity of the fruit is commonly related to the high content of vitamin C, anthocyanins, flavonoids, and polyphenols, which have hydrogen donating capabilities against free radicals such as nitric oxide (NO) [ 56 ]. The administration of methanol extract of the fruit of S. apetala to Long–Evans male rats inhibits the nitrite production in a dose-dependent manner.…”

Section: Nutrition Composition and Bioactivity Of Mangrove Fruit Extractmentioning

confidence: 99%

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Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

et al. 2022

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Nowadays, the logarithmic production of existing well-known food materials is unable to keep up with the demand caused by the exponential growth of the human population in terms of the equality of access to food materials. Famous local food materials with treasury properties such as mangrove fruits are an excellent source to be listed as emerging food candidates with ethnomedicinal properties. Thus, this study reviews the nutrition content of several edible mangrove fruits and the innovation to improve the fruit into a highly economic food product. Within the mangrove fruit, the levels of primary metabolites such as carbohydrates, protein, and fat are acceptable for daily intake. The mangrove fruits, seeds, and endophytic fungi are rich in phenolic compounds, limonoids, and their derivatives as the compounds present a multitude of bioactivities such as antimicrobial, anticancer, and antioxidant. In the intermediary process, the flour of mangrove fruit stands as a supplementation for the existing flour with antidiabetic or antioxidant properties. The mangrove fruit is successfully transformed into many processed food products. However, limited fruits from species such as Bruguiera gymnorrhiza, Rhizophora mucronata, Sonneratia caseolaris, and Avicennia marina are commonly upgraded into traditional food, though many more species demonstrate ethnomedicinal properties. In the Middle East, A. marina is the dominant species, and the study of the phytochemicals and fruit development is limited. Therefore, studies on the development of mangrove fruits to functional for other mangrove species are demanding. The locally accepted mangrove fruit is coveted as an alternate food material to support the sustainable development goal of eliminating world hunger in sustainable ways.

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Section: Nutrition Composition and Bioactivity Of Mangrove Fruit Extractmentioning

confidence: 99%

Section: Nutrition Composition and Bioactivity Of Mangrove Fruit Extractmentioning

confidence: 99%

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

et al. 2022

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“…These plants have a various assemblage of bioactive compounds and it has a crucial factor in antifouling (AF) properties, and these components can be used as natural resources for antifoulers and are eco-friendly in nature (Sahoo et al, 2012;Mulyani et al, 2013;Nandhini and Revathi 2016;Syahputra and Almuqaramah 2019). Few mangrove species have been reported to possess biological properties such as antibacterial (Chandrakala et al, 2017), antiviral (Zandi et al, 2008), anti-diarrheal (Misra et al, 2011), antifeedant (Parthiban et al, 2022), insecticidal (Manilal et al, 2009) and cytotoxic impact (Han et al, 2007). In agreement, mangroves' secondary metabolites, including alkaloids, phenolics, steroids, and terpenoids have been identified.…”

Section: Introductionmentioning

confidence: 99%

Studies on Antifouling Activity of Methanolic Extract of the Mangrove Rhizophora apiculata against Micro and Macro Foulers

Anjana¹,

Rameshbabu²,

Kumar³

et al. 2023

Intern. J. Zool. Invest.

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The antifouling activity and toxic properties of mangroves Acrostichum aureum, Bruguiera gymnorhiza, Rhizophora apiculata, and Sesuvium potrulacastrum are documented in this study. Among the extracts prepared using solvents, the methanolic form of R. apiculata had the highest antimicrofouling and antimacrofouling properties. The minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of R. apiculata methanolic extract significantly reduced the development of all the investigated biofilm bacterial strains at 125 g ml -1 except for Vibrio sp1, Vibrio sp2, and Pseudomonas sp., where it registered MIC at 250 µg ml -1 to 350 g ml -1 . The extract's minimum bactericidal concentration (MBC) was determined to be between 250 and 750 µg ml -1 . Most of the fouling microalgal strains, such as Nitzschia sp., Amphora sp., Tetraselmis sp. and Chaetocerous sp. were found to have had their growth inhibited by the methanolic extract of R. apiculata. However, it registered noticeably higher MICs of 400 µg ml -1 for Chaetocerous sp. and Dunaliella sp. The methanolic extract of R. apiculata has shown promising molluscicidal activity by strongly reducing the adhesion of the limpet Patella vulgate with increasing doses (1-12 mg ml -1 ). The methanolic extract of R. apiculata inhibited the growth of mussel (Perna indica) byssus thread and had an LC50 value of 424.47± 4.85 µg ml -1 after 72 h of exposure. The LC50 value for anticrustacean activity of R. apiculate methanolic extract was 39.4±1.45 µg ml -1 for larvae of Artemia salina. The potential antimicro and antimacrofouling activity of R. apiculata methanolic extract suggested that it is a good source of antifouling agent, and this knowledge was used to develop a potent eco-friendly antifouling molecule.

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“…Several bioactive compounds with diverse effects, including insecticidal, antioxidant, and antimicrobial properties, have been extracted from mangrove plants (Rozirwan et al, 2020(Rozirwan et al, , 2023b . Various biologically active compounds, including limonoids, alkaloids, glycosides, terpenoids, steroids, flavonoids, esters, phenols, lactones, aliphatic alcohols, amides, acids, aliphatic ketones, quinones, and benzodioxols, have been extracted from different parts of mangrove trees, such as bark, stems, leaves, fruits, and seeds (Parthiban et al, 2023) . The Sonneratia genus thrives continuously in coastal areas where land meets the sea, encountering difficulties like oxygen-deprived soil, increased salinity, and strong ultraviolet radiation throughout the year (Nasrin et al, 2021) .…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity and Phytochemical Profile from the Leaves of the Mangrove Sonneratia caseolaris (L.) Engl. for Future Drug Discovery

Rozirwan,

Siswanto,

Khotimah

et al. 2024

Sci. Technol. Indones

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The increasing demand for effective and natural anti-inflammatory agents prompts an investigation into the properties of Sonneratia caseolaris (L.) Engl., a plant traditionally used in medicine. This study aimed to explore the ability of S. caseolaris leaves extract to inhibit inflammation and accelerate wound healing. S. caseolaris leaves were collected from Tanjung Api-Api area, Banyuasin, South Sumatra. The method involved carrageenan induction in rat paws as an inflammatory model. The results showed that the most effective dose was found in the group with a dose of 150 mg/kg BW measured using a digital caliper and plethysmometer. The qualitative phytochemical test contain alkaloids, steroids, flavonoids, and phenols. The results GC-MS analysis were thought to contain aldehydes, glucosinolates, coumarins, esters, terpenoids, alcohols, lipids, tocopherols, and steroids. Due to their diverse range of mechanisms of action, coumarins show significant promise in mitigating inflammation and hold potential for treating inflammatory conditions. This study provides new insights related to the potential of S. caseolaris as a source of natural anti-inflammatory agents, supporting public comprehension regarding the utilization of traditional herbal remedies.

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An integrative review on bioactive compounds from Indian mangroves for future drug discovery

Cited by 14 publications

References 79 publications

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

Studies on Antifouling Activity of Methanolic Extract of the Mangrove Rhizophora apiculata against Micro and Macro Foulers

Anti-Inflammatory Activity and Phytochemical Profile from the Leaves of the Mangrove Sonneratia caseolaris (L.) Engl. for Future Drug Discovery

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