An intelligent and biocompatible photosensitizer conjugated silicon quantum dots–MnO<sub>2</sub> nanosystem for fluorescence imaging-guided efficient photodynamic therapy

Wang, Ronggui; Zhao, Mengyao; Deng, Di; Ye, Xin; Zhang, Fan; Chen, Hui; Kong, Jilie

doi:10.1039/c8tb00931g

Cited by 33 publications

(16 citation statements)

References 60 publications

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“…Additionally Si QDs were modified with MnO 2 , which is known to produce oxygen in the reaction with the endogenous excess metabolites (H 2 O 2 ) in acidic tumour microenvironment. The developed Si-based carriers enabled enhanced loading capacity with PSs and dualimaging properties [fluorescence and magnetic resonance tomography, magnetic resonance imaging (MRI)], which resulted in significant inhibition of HeLa-bearing tumour in vivo [132].…”

Section: Si Npsmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

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Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination of different therapeutic modalities (chemotherapy, photodynamic therapy, and so forth) with light-responsive carriers enables promising synergetic effect in tumour treatment. The main goal of this review article is to provide the state of the art on light-sensitive delivery systems with the identification of future directions and their implementation in tumour treatment. In particular, this article reviews the general information on the physical and chemical fundamental mechanisms of interaction between light and carrier systems (e.g. plasmonic and dielectric nanoparticles), the design of optically responsive drug carriers (plain and composite), and the mechanisms of light-driven controlled release of bioactive compounds in biological environment. The special focus is dedicated to the most recent advances in optically responsive bioinspired drug vehicles.

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Section: Si Npsmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

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Section: Epr Effect and Active Targetingmentioning

confidence: 99%

Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

et al. 2019

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River Scholar of China and the Foreign Academicians of the Russian Academy of Engineering and Russian Academy of Science. Her research interests mainly focus on bioeffects and safety evaluation of nanomaterials and environmental pollution analysis and control. Rui L. Reis obtained his Ph.D. and D.Sc. in polymer engineering-biomaterials & tissue engineering from the University of Minho, Portugal. He is vice president for Research and Innovation of UMinho and the director of the 3B's Research Group and ICVS/3B's Associate Laboratory. He is a full professor of Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho and honorary professor in four different Asian Universities. His main area of research is the development of biomaterials from natural origin polymers, and using those in combination with different stem cells for several strategies for tissue engineering and regenerative medicine, applied to distinct human tissues.

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“…Zhu et al [92] Zhu et al [93] designed a multifunctional theranostic NP (NMOFs@BSA/SDs@MnO 2 ) with nanoscale metal organic frameworks (NMOFs, composed of TCPP as ligand and Fe 3+ ), bovine serum albumin (BSA) and sulfadiazines (SDs), to provide actively targeting for the over-expressed carbonic anhydrase IX (CA IX) in tumour cells, and MnO 2 . NPs presented an average hydrodynamic diameter of 122 nm and its ability to produce O 2 was also proved.…”

Section: Mnomentioning

confidence: 99%

“…Zhang et al [99] developed an O 2 -generating and pH-sensitive nanoplatform, loading MnO 2 for O 2 generation, g-C 3 N 4 for PDT, ZIF-8 (zeolitic imidazolate frameworks) for drug encapsulation and doxorubicin hydrochloride for chemotherapy ( Figure 17). Zhu et al [92] synthesized hybrid semiconductor NPs (SPN-Ms) composed of semiconducting polymer NPs (SPN) as a core and MnO2 nanosheets as a shell. The SPN core served as the NIR agent for fluorescence imaging and PDT, while the MnO2 nanoribbons as O2 formation agent.…”

Section: Mnomentioning

confidence: 99%

Fighting Hypoxia to Improve PDT

et al. 2019

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Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective blood distribution. Moreover, PDT consumes O2. In order to improve the oxygenation of tumour or decrease hypoxia, different strategies are developed and are described in this review: 1) The use of O2 vehicle; 2) the modification of the tumour microenvironment (TME); 3) combining other therapies with PDT; 4) hypoxia-independent PDT; 5) hypoxia-dependent PDT and 6) fractional PDT.

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An intelligent and biocompatible photosensitizer conjugated silicon quantum dots–MnO₂ nanosystem for fluorescence imaging-guided efficient photodynamic therapy

Abstract: We constructed an intelligent and biocompatible BSA–Ce6–Si QDs–MnO2 nanocomplex as a pH/H2O2 responsive photosensitizer nanocarrier for fluorescence imaging-guided photodynamic therapy (PDT).

Cited by 33 publications

References 60 publications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Fighting Hypoxia to Improve PDT

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An intelligent and biocompatible photosensitizer conjugated silicon quantum dots–MnO2 nanosystem for fluorescence imaging-guided efficient photodynamic therapy

Abstract: We constructed an intelligent and biocompatible BSA–Ce6–Si QDs–MnO2 nanocomplex as a pH/H2O2 responsive photosensitizer nanocarrier for fluorescence imaging-guided photodynamic therapy (PDT).

Cited by 33 publications

References 60 publications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Fighting Hypoxia to Improve PDT

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An intelligent and biocompatible photosensitizer conjugated silicon quantum dots–MnO₂ nanosystem for fluorescence imaging-guided efficient photodynamic therapy