An Intelligent and Efficient Workflow for Path-Oriented 3D Bioprinting of Tubular Scaffolds

Baroth, Timo; Loewner, Sebastian; Heymann, Henrik; Cholewa, Fabian; Blume, Holger; Blume, Cornelia

doi:10.1089/3dp.2022.0201

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…IPA can also be used to streamline and optimise the manufacturing process. For example, IPA systems could be used to monitor and control the various steps involved in the production of edible scaffold materials, such as the mixing of ingredients and the shaping of the scaffold structures (Baroth et al, 2024). AI and ML can be used to monitor CM cell growth on the scaffold by analysing data from sensors that measure factors such as temperature, pH and nutrient levels (Al-Kharusi et al, 2022).…”

Section: Scaffoldingmentioning

confidence: 99%

Industry 4.0 technologies for cultivated meat manufacturing

Kamalapuram,

Choudhury

2024

Food Bioengineering

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Industry 4.0 integrates the physical, digital, and biological realms by applying digital automation in systems, processes, and manufacturing facilities. Industry 4.0 is actively shaping the development of intelligent food processing industries in cultivated meat (CM) sector. This integration plays a crucial role in accelerating progress within the global CM sector, facilitating the achievement of its objectives related to food sustainability, security, human health, environmental concerns, and hygiene. Incorporating Industry 4.0 into CM manufacturing systems empowers upstream and downstream production processes to become more intelligent and capable of self‐optimisation. However, enabling rapid adoption of Industry 4.0 by emerging startups and small to medium‐sized enterprises in the CM industry necessitates a thorough understanding of prerequisites and evaluation of technological and biological limitations. Challenges include the substantial initial costs associated with establishing Industry 4.0 infrastructure, robust cybersecurity measures to ensure effective risk management, and acquiring skilled professionals proficient in both operational and maintenance roles. Integrating Industry 4.0 with the evolving CM sector presents an exciting opportunity to foster business‐to‐business investments across various domains, including local markets, export opportunities, and the broader global consumer ecosystem.

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Section: Scaffoldingmentioning

confidence: 99%

Industry 4.0 technologies for cultivated meat manufacturing

Kamalapuram,

Choudhury

2024

Food Bioengineering

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The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

Bartolf‐Kopp,

Jungst

2024

Adv Healthcare Materials

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Melt Electrowriting (MEW) is a continuously growing manufacturing platform. Its advantage is the consistent production of micro‐ to nanometer fibers, that stack intricately, forming complex geometrical shapes. MEW allows tuning of the mechanical properties of constructs via the geometry of deposited fibers. Due to this, MEW can create complex mechanics only seen in multi‐material compounds and serve as guiding structures for cellular alignment. The advantage of MEW is also shown in combination with other biotechnological manufacturing methods to create multilayered constructs that increase mechanical approximation to native tissues, biocompatibility, and cellular response. These features make MEW constructs a perfect candidate for small‐diameter vascular graft structures. Recently, studies have presented fascinating results in this regard, but is this truly the direction that tubular MEW will follow or are there also other options on the horizon? This perspective will explore the origins and developments of tubular MEW and present its growing importance in the field of artificial small‐diameter vascular grafts with mechanical modulation and improved biomimicry and the impact of it in convergence with other manufacturing methods and how future technologies like AI may influence its progress.

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Ink-structing the future of vascular tissue engineering: a review of the physiological bioink design

Synofzik,

Heene,

Jonczyk

et al. 2024

Bio-des. Manuf.

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Three-dimensional (3D) printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and organs. These tissue-engineered structures are intended to integrate with the patient’s body. Vascular tissue engineering (TE) is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered constructs. Bioinks have a specific role, representing the necessary medium for printability and vascular cell growth. This review aims to understand the requirements for the design of vascular bioinks. First, an in-depth analysis of vascular cell interaction with their native environment must be gained. A physiological bioink suitable for a tissue-engineered vascular graft (TEVG) must not only ensure good printability but also induce cells to behave like in a native vascular vessel, including self-regenerative and growth functions. This review describes the general structure of vascular walls with wall-specific cell and extracellular matrix (ECM) components and biomechanical properties and functions. Furthermore, the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is introduced. Diverse currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular bioprinting. The physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting, with a view to current animal studies of 3D printed vascular structures. Finally, the main challenges for further bioink development, suitable bioink components to create a self-assembly bioink concept, and future bioprinting strategies are outlined. These concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.

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An Intelligent and Efficient Workflow for Path-Oriented 3D Bioprinting of Tubular Scaffolds

Cited by 5 publications

References 27 publications

Industry 4.0 technologies for cultivated meat manufacturing

Industry 4.0 technologies for cultivated meat manufacturing

The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process?

Ink-structing the future of vascular tissue engineering: a review of the physiological bioink design

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