An Interaction of Testosterone with Cell Membranes

Díez, Adolfo; Mj, Sancho; M, Egaña; Trueba, Miguel; Marino, Aída; Jm, Macarulla

doi:10.1055/s-2007-1014823

Cited by 26 publications

(12 citation statements)

References 4 publications

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“…Paradoxically, they are significantly depleted with respect to controls. This is in agreement with that found previously for testosterone (Diez et al, 1984).…”

Section: Discussionsupporting

confidence: 94%

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Two Independent Effects of Cortisol on Chicken Liver

Sancho¹,

M²,

Trueba³

et al. 2009

Exp Clin Endocrinol Diabetes

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Activities of two key enzymes of glycogen metabolism have been measured after an acute administration of cortisol to 3d-old chickens. Glycogen synthase activity is enhanced 2-3 hours after a cortisol injection, and this activation is blocked by use of protein synthesis inhibitors. Glycogen phosphorylase activity is enhanced at an early stage, and this effect is not suppressed by protein synthesis inhibitors. Liver cAMP levels are not increased concomitantly with this early activation of glycogen phosphorylase; indeed they are depleted. These results point to the existence of an effect of cortisol previous to and independent of its nuclear interaction, and not mediated by an activation of the membrane adenylate cyclase.

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“…Paradoxically, they are significantly depleted with respect to controls. This is in agreement with that found previously for testosterone (Diez et al, 1984).…”

Section: Discussionsupporting

confidence: 94%

“…However, the first effect, because it is present even when protein synthesis is inhibited, seems to be a consequence of a hormone interaction with another cellular organelle, before the hormone reaches the nucleus, due to the shorter lag time. We have proposed for testosterone an interaction with the plasma membrane (Diez et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Two Independent Effects of Cortisol on Chicken Liver

Sancho¹,

M²,

Trueba³

et al. 2009

Exp Clin Endocrinol Diabetes

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“…Based on rapid actions of testosterone, non-genomic effects of androgens were proposed over 30 years ago (9). Further, AR’s have been localized at extranuclear sites, such as hippocampal dendritic spines (10) and axons of the cerebral cortex (11).…”

Section: Androgen Receptors In Brainmentioning

confidence: 99%

Androgen Receptors, Sex Behavior, and Aggression

2012

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Androgens are intricately involved in reproductive and aggressive behaviors, but the role of the androgen receptor in mediating these behaviors is less defined. Further, activity of the hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-adrenal axis can influence each other at the level of the androgen receptor. Knowledge of the mechanisms for androgens’ effects on behaviors through the androgen receptor will guide future studies in elucidating male reproductive and aggressive behavior repertoires.

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“…This nuclear effect of glucocorticoids on the enzymes of glycogen metabolism has been recently documented by Hers (1985). However, in contrast with it, an early glycogenolytic effect, independent of protein synthesis enhancement, has been accounted (Egaña et al, 1981;Vallejo et al, 1986;Sancho et al, 1986), in animals treated with cortisol or other steroid hormones (Diez et al, 1984;Sánchez-Bueno et al, 1987). Dexamethasone, a synthetic analogue of cortisol, also elicits phosphorylase activation (Fig.…”

Section: Discussionmentioning

confidence: 87%

Increased Phospholipid Methylation and Glycogen Phosphorylase Activation after a Single Dose of Dexamethasone in Mouse Liver

Marino

Bartolomé²,

Trueba³

et al. 2009

Exp Clin Endocrinol Diabetes

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Two different effects on phospholipid methylation and glycogen phosphorylase a activation were accomplished by treating mice livers with dexamethasone. A biphasic effect on the glycogen phosphorylase a was determined in the homogenated liver of dexamethasone-treated animals: The enzymatic activity increased between 45 to 90 min and decreased about 3 h. Moreover, the increased activity of glycogen phosphorylase a was also found in adrenalectomized mice. Also, the incorporation of ethanolamine into PE1) and PC1) after 15 min of hormone-administration was 77% and 270%, respectively, over the control values. The increase in phospholipid methylation was maintained during the first hour. After 4 h the hormone-treated animals also showed significant differences compared to the controls. Finally, studies of total lipid phosphorus content in the liver fail to show any differences between control and hormone-treated mice.

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An Interaction of Testosterone with Cell Membranes

Cited by 26 publications

References 4 publications

Two Independent Effects of Cortisol on Chicken Liver

Two Independent Effects of Cortisol on Chicken Liver

Androgen Receptors, Sex Behavior, and Aggression

Increased Phospholipid Methylation and Glycogen Phosphorylase Activation after a Single Dose of Dexamethasone in Mouse Liver

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