An interrelationship between neuroinflammation and progression of Alzheimer's disease (AD) / A inter-relação entre a neuroinflamação e a progressão da Doença de Alzheimer (DA)

Abstract

Alzheimer's disease (AD) is among the major neurodegenerative diseases in the world, characterized by progressive decline in cognitive abilities, behavioral abnormalities and functional loss in daily activities. Several studies indicate the effectiveness of using biomarkers as a diagnostic source of the disease, as well as suggesting the analysis of inflammatory cytokines as accompanying factors. There are several inflammatory cytokines that are well described in the pathogenesis of AD, such as Interleukin-6 (IL-6), IL-1ß, tumor necrosis factor (TNF-), oxidative stress, among others. Some chemokines, although presenting a protective and modulating character of neuroinflammation, also appear as proinflammatory proteins, depending on the course of the disease, such as CX3C. This review considers that neuroinflammation has a degenerative character in the Central Nervous System (CNS), and understands that it needs more evidence regarding these data, especially in the pharmacotherapy question.