An Introduction to the Measurement of the Cerebral Oxygen Uptake Rate by Inhalation of ¹⁵O₂: Analysis of the Contribution of ¹⁵O₂ and H₂^I5O in Brain Radioactivity

Abstract

This paper introduces a model for the computation of the regional cerebral metabolic rate of oxygen from the data of cerebral regional radioactivity collected after inhalation of ¹⁵O₂. A method was devised for the differential determination of the respective contribution of radiooxygen and of radiowater in the inflow and the outflow of radioactivity in the brain after or during such on inhalation. The results demonstrate the feasability of such a model and outline some of the methodological prerequisites to be taken into account in the numerical analysis of the data.