An Introduction to the Relationship Between Lewis x and Malignancy Mainly Related to Breast Cancer and Head Neck Squamous Cell Carcinoma (HNSCC)

Croce, María Virginia

doi:10.1080/07357907.2021.2016800

Cited by 6 publications

(5 citation statements)

References 78 publications

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“…Another malignancy is confirmed to express CD15 antigen on the surface of its cells in breast cancer [48,49]. Similarly to lung adenocarcinoma, CD15 and CD15s are established key antigens in breast cancer progression and metastasis, enabling endothelial adhesion [18].…”

Section: Role Of Cd15 and Cd15s In Neoplasmsmentioning

confidence: 99%

CD15 and CD15s in The Anticancer Therapy

Szlasa¹,

Wilk²,

Knecht-Gurwin³

et al. 2022

Preprint

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CD15 (Lewis X/Lex) is a fucosyl (3-fucosly-N-acetyl-lactosamine) moiety found on membrane proteins of various cancer cells. These include renal cancer, prostate and bladder cancers, acute leukemias, hepatocellular carcinoma, breast cancer and melanoma. The antigen plays an espe-cially significant role in renal cell carcinoma. Its high expression serves as a good prognostic marker for patients and high hopes are related to its use in the immunotherapy of the tumor. The biological role of CD15 is the interaction with E-, L- and P-selectins (adhesion molecules) and al-lowing for the adhesion with the endothelial cells. In this way, cancer cells start to interact with the endothelium of blood vessels and consequently move out from the blood flow to the sur-rounding tissues. The blockage of antigen’s function results in reduced metastatic potential. Moreover, the molecule may be a therapeutic target against cancer in monoclonal antibod-ies-based therapies. CD15s is a sialyl derivative of CD15, that possess its own unique characteris-tics. Unlike high expression of CD15, which is a prognostic factor in Hodgkin lymphoma, CD15s relate to poor prognosis for the patients. Due to the high abundance in cancer cells, CD15 is con-sidered as a marker of Cancer Stem Cells. This review presents a comprehensive description of the role of CD15 and CD15s in cancer development and metastasis and overviews the clinical appli-cations of the anti-CD15 therapy.

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Section: Role Of Cd15 and Cd15s In Neoplasmsmentioning

confidence: 99%

CD15 and CD15s in The Anticancer Therapy

Szlasa¹,

Wilk²,

Knecht-Gurwin³

et al. 2022

Preprint

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“…In contrast, only two lncRNAs were hit based on the original lncRNA list, as shown in Table 4 . The experimental results of this case have previously shown that there is a certain relationship between breast cancer and head and neck squamous cell carcinoma ( Croce, 2022 ), which also indicates that the TLSEA can detect some new diseases ignored by conventional enrichment analysis methods.…”

Section: Resultsmentioning

confidence: 63%

TLSEA: a tool for lncRNA set enrichment analysis based on multi-source heterogeneous information fusion

Wang

et al. 2023

Front. Genet.

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Long non-coding RNAs (lncRNAs) play an important regulatory role in gene transcription and post-transcriptional modification, and lncRNA regulatory dysfunction leads to a variety of complex human diseases. Hence, it might be beneficial to detect the underlying biological pathways and functional categories of genes that encode lncRNA. This can be carried out by using gene set enrichment analysis, which is a pervasive bioinformatic technique that has been widely used. However, accurately performing gene set enrichment analysis of lncRNAs remains a challenge. Most conventional enrichment analysis methods have not exhaustively included the rich association information among genes, which usually affects the regulatory functions of genes. Here, we developed a novel tool for lncRNA set enrichment analysis (TLSEA) to improve the accuracy of the gene functional enrichment analysis, which extracted the low-dimensional vectors of lncRNAs in two functional annotation networks with the graph representation learning method. A novel lncRNA–lncRNA association network was constructed by merging lncRNA-related heterogeneous information obtained from multiple sources with the different lncRNA-related similarity networks. In addition, the random walk with restart method was adopted to effectively expand the lncRNAs submitted by users according to the lncRNA–lncRNA association network of TLSEA. In addition, a case study of breast cancer was performed, which demonstrated that TLSEA could detect breast cancer more accurately than conventional tools. The TLSEA can be accessed freely at http://www.lirmed.com:5003/tlsea.

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“…While LeX is expressed in a wide range of solid tumors, unraveling the functional implications of its presence on cancer cells has not been trivial (reviewed by Croce 29 ). However, for breast cancer patients, two studies have associated LeX with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

SSEA-1 Correlates With the Invasive Phenotype in Breast Cancer

Kohler

Hansen

Kim

et al. 2023

J Histochem Cytochem.

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The glycan moiety Lewis X (LeX) has been implicated in defining progenitor cells as well as playing a role in the progression of solid tumors, including breast cancer. Here, we used the original stage-specific embryonic antigen-1 (SSEA-1) antibody, MC-480, targeting the LeX motif to examine the expression pattern of this marker within the context of a differentiation hierarchy as well as functional properties of breast cancer cells. Immunohistochemical staining revealed the presence of SSEA-1 in a progenitor zone in the normal breast gland. In breast cancer, 81 of 220 carcinomas (37%) were positive for SSEA-1 and a distinct pattern could be correlated to major subtypes. Specifically, estrogen receptor alpha (ERα)-negative tumors showed a higher frequency of SSEA-1 expression compared to ERα-positive tumors, which are generally considered more differentiated (56% vs 29%, p<0.005). Functional assays performed on two representative breast cancer cell lines demonstrated that SSEA-1-expressing cells exhibited cancer stem cell properties as well as having more invasive potential, regardless of ERα status. A potential role of SSEA-1 in metastasis was confirmed by pairwise staining of primary- and corresponding lymph node tumors. Altogether, our data suggest that expression of SSEA-1 in breast cancer contributes to the malignant phenotype:

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An Introduction to the Relationship Between Lewis x and Malignancy Mainly Related to Breast Cancer and Head Neck Squamous Cell Carcinoma (HNSCC)

Cited by 6 publications

References 78 publications

CD15 and CD15s in The Anticancer Therapy

CD15 and CD15s in The Anticancer Therapy

TLSEA: a tool for lncRNA set enrichment analysis based on multi-source heterogeneous information fusion

SSEA-1 Correlates With the Invasive Phenotype in Breast Cancer

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