The arrival of various mechanism applications to healthcare is gaining more attention with various novel breakthroughs in digitalizing healthcare. The use of technology in improving the delivery of healthcare comprises various applications such as electronic health systems, telemedicine, mobile health, remote patient monitoring, and wearable devices. Wearables and implants are making a significant impact on revolutionizing healthcare globally, and the next generation of advanced technology is providing adequate applications in tackling the challenges in digital healthcare. The advancement of various techniques gives future direction to digitalizing healthcare. Antennas play a key part in digitalizing healthcare because of their characteristics and the adaptation to wireless communication with transmission and reception in different human body parts. Although there are a lot of studies done and published on digital healthcare, telemedicine, wearable, and many more mechanisms that enhance healthcare delivery, however, systematic studies that comprehensively review the applications in healthcare such as wearable antenna framework remain scarce. This paper attempts to close the gap in investigating mechanisms for digital health care, and wearable devices with antenna applications. This comprehensive systematic review covers antenna application in healthcare. Furthermore, it provides a state-of-the-art update on recent developments in healthcare with a focus on design, monitoring devices, diagnostic implants, early detection mechanisms, and control. We also examine wearable analysis and performance, fabrication and experimental approaches, and the major types of wearables. This assists with existing chronic disease management and future epidemics with provided tools. This finding will give a blueprint of how zero spread of future epidemics will be achieved by implementing the bio-electromagnetic application in the healthcare sector.