An investigation of the tremorgenic actions of harmine in the rat

Cox, B.; Potkonjak, D.

doi:10.1016/0014-2999(71)90054-9

Cited by 30 publications

(13 citation statements)

References 17 publications

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“…Beta-adrenergic blockers such as propranolol suppress harmaline and harmine tremor in rodents 111, 112. Selective beta 1 - and beta 2 -adrenergic antagonists can each suppress harmaline tremor in rats, but beta 2 -blockade may be more effective 113.…”

Section: Resultsmentioning

confidence: 99%

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Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor

Handforth

2012

Tremor and Other Hyperkinetic Movements

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Section: Resultsmentioning

confidence: 99%

“…Anticholinergics do not reduce harmine tremor in rodents 111. Harmaline tremor is suppressed by systemic lidocaine (12.5–50 mg/kg);142 dantrolene, 10 mg/kg;124 lithium, 2 mEq,118 in mice; and 16-methyl-prostaglandin E 2 (PGE 2 ), 25–50 μg/kg, in cats 143.…”

Section: Resultsmentioning

confidence: 99%

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor

Handforth

2012

Tremor and Other Hyperkinetic Movements

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“…(1 -methyl-7-methoxy-Q-carbo line) is a tremorgenic alkaloid and induces tremors in rats and mice (1)(2)(3)(4). We have reported that administration of harmine in combination with apomorphine induces violent jumping in rats instead of a tremor.…”

Section: Harminementioning

confidence: 99%

Estimation of harmine and its derivatives by HPLC : Correlation of brain harmine levels with jumping behavior in rats.

Moroi

Kuga

1987

Jpn.J.Pharmacol

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Abstract-Brainharmine was simply and sensitively determined by high perfor mance liquid chromatography (HPLC), and the relationship between brain harmine concentrations and the jumping behavior induced by harmine and apomorphine was investigated. The concentration of harmine and the peak height in HPLC showed a good correlation, and the detection limit was 0.05 pmole harmine.In rats treated with 2, 5 and 10 mg/kg of harmine, the concentrations of harmine in the brain cortex were 9.0, 21.3 and 43.1 nmole/g tissue (wet wt.), respectively. The regional brain harmine concentrations and the jumping activity measuring by a scoring system increased with increasing doses of harmine administered, and there was a direct relation between the harmine concentrations and the jumping activity. This relation was observed in washed membranes in which about 40% of the harmine in whole homogenate was present. Tissue subfractionation showed that 30% of the harmine in whole brain homogenates was in the P2 fraction, and of this, 70% was located in the synaptosomes. The brain homogenate did not metabolize harmine and no metabolite was detected in the brain 10 min after treat ment with harmine and apomorphine.These results suggest that harmine itself, but not its metabolites, may be responsible for inducing the jumping behavior and that the jumping activity is correlated with brain harmine concentrations.

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“…is a tremorgenic alkaloid and induces tremors in rats and mice (1)(2)(3). We have demonstrated that administration of harmine in combination with apomorphine (APO) induced a violent jumping in rats instead of a tremor.…”

mentioning

confidence: 99%

Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats.

Moroi

Takashi²,

Kuga

1988

Jpn.J.Pharmacol

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Abstract-Harmine(HA) induces a jumping behavior in rats when the central dopaminergic function has been activated.Possible involvement of the GABAergic systems and the benzodiazepine receptors (BZA-R) in the jumping behavior induced by HA and apomorphine (APO) was investigated. Pretreatment with GABAergic agonists, muscimol (0.05-0.2 mg/kg) and diazepam (0.2-1.0 mg/kg), and an tagonists, picrotoxin (0.1-0.5 mg/kg) and bicuculline (0.1-0.5 mg/kg), suppressed the jumping behavior in a dose-dependent manner in rats treated with HA (10 mg/ kg) and APO (2 mg/kg).After treatment with 2, 5 or 10 mg/kg of HA in combi nation with 2 mg/kg of APO, a decrease in 3H-diazepam binding to the brain regional membranes was observed in the corpus striatum (CS) in a dose-dependent manner, but not in the other brain regions.The decrease in the 3H-diazepam binding to the CS membranes was proportional to the increase in the HA levels in the CS, and the HA levels were correlated with the intensity of jumping behavior. Pretreatment with Ro 15-1788, an antagonist of BZA-R, suppressed the jumping behavior induced by HA and APO. These results indicated the involvement of the GABAergic systems in the jumping behavior and suggested that HA induced the jumping behavior partly as a result of interacting with the BZA-R.

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An investigation of the tremorgenic actions of harmine in the rat

Cited by 30 publications

References 17 publications

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor

Estimation of harmine and its derivatives by HPLC : Correlation of brain harmine levels with jumping behavior in rats.

Involvement of GABAergic systems and benzodiazepine receptors in the jumping behavior induced by harmine and apomorphine in rats.

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