An invited commentary: The efficacy of transversus abdominis plane block with or without dexmedetomidine for postoperative analgesia in renal transplantation. A randomized controlled trial

Zhu, Yuhang; Gong, Taowu

doi:10.1016/j.ijsu.2020.07.008

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…DBP causes oxidative stress in the lung and kidney, and the overproduction of reactive oxygen species (ROS) is the main reason for its toxicity. 17,18 ROS refers to oxygen-containing and active chemical substances. 19 When exposed to external stimuli, the body will produce a large amount of ROS and cause oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

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Dibutyl phthalate causesMC3T3‐E1cell damage by increasingROSto promote thePINK1/Parkin‐mediated mitophagy

Cui

et al. 2022

Environmental Toxicology

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Dibutyl phthalate (DBP) is a plasticizer widely used in daily production, which causes serious environmental pollution, and damage to brain, liver, kidney, and lung by producing excessive reactive oxygen species (ROS) after entering the body. DBP can also cause skeletal dysplasia, but it is unclear whether ROS is involved. In addition, overproduction of ROS can activate mitophagy, which is an important mechanism for regulating mitochondrial quality and cell homeostasis. In order to investigate whether DBP can damage MC3T3‐E1 cells (osteoblast cell line) and whether ROS and mitophagy are involved, DBP toxicity experiment, Parkin gene silencing experiment, and N‐acetylcysteine (NAC) intervention experiment were performed on MC3T3‐E1 cells in turn. First, we found that DBP caused MC3T3‐E1 cell viability decline and osteogenic dysfunction, accompanied by the overproduction of ROS and the activation of mitophagy. Then, we found that silencing Parkin expression alleviated DBP‐induced apoptosis and osteogenic dysfunction of MC3T3‐E1 cells. In addition, NAC treatment inhibited the PINK1/Parkin‐mediated mitophagy and alleviated the apoptosis and osteogenic dysfunction of MC3T3‐E1 cells caused by DBP. Our research results showed that DBP could cause MC3T3‐E1 cell damage by increasing ROS to promote the PINK1/Parkin‐mediated mitophagy.

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Section: Introductionmentioning

confidence: 99%

“…DBP causes oxidative stress in the lung and kidney, and the overproduction of reactive oxygen species (ROS) is the main reason for its toxicity 17,18 . ROS refers to oxygen‐containing and active chemical substances 19 .…”

Section: Introductionmentioning

confidence: 99%

Dibutyl phthalate causesMC3T3‐E1cell damage by increasingROSto promote thePINK1/Parkin‐mediated mitophagy

Cui

et al. 2022

Environmental Toxicology

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Preparation of positively charged acid-resistant hollow fiber nanofiltration membrane with excellent separation performance by surface modification

Wu,

Wang,

Liu

et al. 2025

Desalination

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An invited commentary: The efficacy of transversus abdominis plane block with or without dexmedetomidine for postoperative analgesia in renal transplantation. A randomized controlled trial

Cited by 2 publications

References 3 publications

Dibutyl phthalate causesMC3T3‐E1cell damage by increasingROSto promote thePINK1/Parkin‐mediated mitophagy

Dibutyl phthalate causesMC3T3‐E1cell damage by increasingROSto promote thePINK1/Parkin‐mediated mitophagy

Preparation of positively charged acid-resistant hollow fiber nanofiltration membrane with excellent separation performance by surface modification

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