An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Moossavi, Maryam; Hoshyar, Reyhane; Hemmati, Mina; Farahi, Ali; Javdani, Hossein

doi:10.1186/s40816-016-0030-7

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…So, organism antioxidant defense system was evaluated by CAT, GPX and SOD activities (17,18). Accordingly, this result strongly prove oxidative stress prevalence in the APAPinduced hepatic damages (19,20). However, the groups that received Protocatechuic acid showed an increase in the by CAT, GPX and SOD activities and a decrease in MDA level.…”

Section: Discussionsupporting

confidence: 59%

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Mousavi

Khodayar

Bazle

et al. 2022

Preprint

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Background Acetaminophen (APAP) is known as a safe drug for the relief of fever and pain at therapeutic levels. However, APAP toxicity is considered as the most general cause of acute hepatic damage. This research aimed to evaluate the protective effects of Protocatechuic acid (PCA), as an antioxidant, on the APAP-induced liver toxicity in mice. Methods In this regard, we treated male ICR mice with 40, 80, and 160 mg/kg PCA followed by 300 mg/kg APAP 1 h later for 7 days. By passing 24 h from the APAP administration, they were sacrificed, their Liver was dissected, and blood samples were collected for the evaluation of liver function. Results The results show that APAP-overdose (300mg/kg, IP) could lead to acute liver injury in mice, which is characterized by a rise in serum liver function tests (AST, ALT), pathological changes, and a decline in the antioxidant defense system. In addition, hepatic MDA levels, as the end product of lipid peroxidation, have increased, while the antioxidant enzymes such as GPX, SOD, and CAT activities have decreased in mice. In contrast, it was shown that pre-treatment with PCA could decline MDA, ALT, and AST levels and obviously attenuate the liver histological damage and the antioxidant enzymes. Finally, the results show that PCA had protective effects on the APAP-induced liver damage in mice. Conclusions Our studies show that hepatoprotective natural agents can be effective in APAP -liver toxicity.

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Section: Discussionsupporting

confidence: 59%

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Mousavi

Khodayar

Bazle

et al. 2022

Preprint

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“…Crocus sativus L. (CS) also popularly known as saffron is a flowering plant belonging to the Iridaceae family and cultivated in countries such as Iran, Spain, Italy, etc., [8]. The chemical composition of the CS varies from region to region, seasonal diversification and flora origin [9].…”

Section: Introductionmentioning

confidence: 99%

Crocus sativus L. Extract Containing Polyphenols Modulates Oxidative Stress and Inflammatory Response against Anti-Tuberculosis Drugs-Induced Liver Injury

Wali

Pillai

Dhaheri

et al. 2020

Plants

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The purpose of this study is to analyze the polyphenolic rich extract of Crocus sativus L. petals (CSP) in modulating liver oxidative stress and inflammatory response status against rifampicin isoniazid (INH-RIF) drug-induced liver injury. The INH-RIF was administered for 14 days with varying doses in Wistar rats, while silymarin was administered as standard dose. We report the defensive impacts of CSP against INH-RIF induced liver oxidative stress and proinflammatory cytokine. The CSP treatment at both doses significantly controlled all modulating biochemical hepatic injury indicators and resulted in the attenuation of arbitral INH-RIF damage. The components present in CSP identified by LC–ESI-Q-TOF–MS were found to be flavonoids and fatty acids. It can be inferred that CSP possesses a hepatoprotective capacity against INH-RIF-mediated hepatic injury, which may prove to be a medically beneficial natural product for the management of drug-induced liver injury.

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“…Hence, they have not been explored intensively in drug discovery, especially those that can inhibit COVID-19 (Dias et al, 2012;Harvey et al, 2015;Benarba & Pandiella, 2020;Lakshmi et al, 2020). Z. spina-christi as important medicinal plant (El Maaiden et al, 2019) is a deciduous tree that generally comes from warm and subtropical climates, such as North Africa, South Europe, Mediterranean, tropical America, South and East of Asia, and others, including Indonesia (Kwape et al, 2013;Moossavi et al, 2017). There are many names for Z. spina-christi, known as Christ's thorn jujube, belongs to the Rhamnaceae family with large shade tree (Baghazadeh-Daryaii et al, 2017;Gorai et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Biological activity, molecular docking, and ADME predictions of amphibine analogues of Ziziphus spina-christi towards SARS-CoV-2 Mpro

Fakih

Ramadhan²,

Darusman

2021

bio

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The main protease of the SARS-CoV-2 virus, SARS-CoV-2 Mpro, can be discovered as a promising target to treat the COVID-19 pandemic. The peptide-based inhibitors may present better options than small molecules for inhibits SARS-CoV-2 Mpro. Ziziphus spina-christi species reported have a peptide-based of alkaloids group, i.e. Amphibine that the analogues can be identified the potential as an inhibitor of SARS-CoV-2 Mpro. The compound structure was drawn and optimized using semi-empirical AM-1 method using Quantum ESPRESSO v.6.6, then the biological activity using PASS Prediction server and molecular docking simulation using MGLTools 1.5.6 with AutoDock 4.2 were performed. Afterward, the ADME profiles were predicted using the SWISS-ADME server. PASS server was predicting Amphibine B-F and H showed potency both as antiviral and as a protease inhibitor. The molecular docking simulation of Amphibine analogues showed lower binding energy than the native ligand. The binding energy of the native ligand was −7.69 Kcal/mol compared to the lowest binding energy of Amphibine analogues was −10.10 Kcal/mol (Amphibine-F). The ADME prediction showed, as an oral drug Amphibine-F has the best bioavailability, Amphibine-B, C, and D have good bioavailability, and Amphibine-E and H have poor bioavailability. Concluded, Amphibine B-F and H of Amphibine analogues showed potency as COVID-19 treatment targeting SARS-CoV-2 Mpro.

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An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Cited by 8 publications

References 26 publications

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Crocus sativus L. Extract Containing Polyphenols Modulates Oxidative Stress and Inflammatory Response against Anti-Tuberculosis Drugs-Induced Liver Injury

Biological activity, molecular docking, and ADME predictions of amphibine analogues of Ziziphus spina-christi towards SARS-CoV-2 Mpro

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