Next-Generation Networks (NGNs) will support Quality of Service (QoS) over a mixed wired and wireless IP-based infrastructure. A relative model of service differentiation in Differentiated Services architecture is a scalable solution for delivering multimedia traffic. However, considering the dynamic nature of radio channels typically, it is difficult to achieve a given service provisioning working at the IP and lower layers separately as in the classical approach, without a run-time adaptation of the system towards the target quality. This work describes an IP cross-layer scheduler able to support a Proportional Differentiation Model (PDM) for delay guarantees with content-awareness, also over wireless. The key idea is to leverage feedbacks from the lower layers about the actual delays experienced by packets in order to tune at run-time the priority of the IP service classes in a closed-loop control with the objective of supporting a PDM at the network node on the whole, considering the cumulative latency in crossing the first three layers of the protocol stack, as relevant for the end-user. A simulation analysis demonstrates the prominent improvements in reliability and robustness of the proposal in the case of time-variant performance of the MAC and PHY layers with respect to the classical non-cross-layer approach and the openloop control. Furthermore, considerations on the required functionality and likely deployment scenarios highlight the scalability and backward compatibility of the designed solution in supporting the concept of network transparency for the delivering of critical applications, as of the e-health domain.