An iron-based T 1 contrast agent made of iron-phosphate complexes: In vitro and in vivo studies

Iron(III) Contrast Agent Candidates for MRI: a Survey of the Structure–Effect Relationship in the Last 15 ­Years of Studies

“…Stronger signals were registered for kidney with moderate clearance, whereas the liver signal was less enhanced and highly dosedependent. Consistently with the high polarities of the catechol plasma [52] [Fe(DSC-L 2 ) 3 ] [56] [Fe 8 (phos)] 7 240 0.04 123 brain tumors of mice (C6 glioma) [56] [Fe(MGD-3-FCAT) 3 ]…”

“…Activation through various stimuli is required, and this quest has also been launched with iron complexes. [20] The work of Rodríguez, in which relaxivity changed with [HPO 4 2-], [56] and Masons' [58] and Yu's [50] studies on the activation of phenol derivatives are good examples. Meanwhile, myriads of gadolinium(III) models will definitely serve as examples to follow.…”

“…[24] Therefore, in vitro studies could give a superficial picture of the redox activity, especially in a comparative manner to the already tested models or to the one used in medicine. However, a more in-depth in vivo investigation cells C6 glioma (MTT) 50 [55] [Fe 8 (phos)] 0.4/0.6/0.8 mice 100/80/60 [56] FAC-S-Gal 2/40 cells Rosa 26 mice labeled with S-Gal-FAC 80/80 [58] FAC-S-Gal 2/40 cells C57BL6 BMCs labeled with S-Gal-FAC 85/ 82 [58] [Fe(MGD-3-FCAT) 3 ] 0 [b] human breast cancer cell MCF7 WT/MCF7-lacZ 100/100 [50] coupled with toxicity studies in different biological materials should give more reliable information on the actual threats and possible side effects.…”

“…[Fe 8 (phos)] was tested on mouse brain tumors; however, it gave weaker contrast enhancement than [Gd(DTPA)] 2-because of the latter compound's higher efficiency in crossing the blood-brain barrier. [56] [Fe(MGD-3-FCAT) 3 ] was examined in human breast MCF7 and prostate PC3 cancer cells. [50] Over 100 % of SI was observed upon activation with β-galactosidase relative to the blind test.…”

Supercritical‐Fluid‐Assisted One‐Pot Synthesis of Biocompatible Core(γ‐Fe2O3)/Shell(SiO2) Nanoparticles as High Relaxivity T2‐Contrast Agents for Magnetic Resonance Imaging

“…[2,3] It is believed that in the near future, iron-based imaging agents will play an increasing significant role in this area, and thus, special attention is given to the fabrication of novel systems with higher relaxivity values. [4][5][6] Specific target iron oxide probes, [7] theranostic applications, [8] as well as, the detection of molecular interactions, [9] are other aspects where fast advances are being reported. In addition, libraries of nanoparticles are being generated.…”