An irregular, extremely broad QRS complex rhythm

Wilgenhof, Adriaan; Michiels, Vincent; Cosyns, Bernard

doi:10.1016/j.ajem.2019.158356

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…To su: triciklični antidepresivi (TCA) [4], citalopram/ escitalopram [5], difenhidramin, propoksifen, antiaritmici (naročito IC klasa-flekainid) [6] i lokalni anestetici: bupivakain, ropivakain [7]. Opisani su slučajevi WCT kao manifestacija kardiotoksičnosti kokaina [9], herbicida (Glifosat) [10], etanola (zajedno sa intoksikacijom propranololom) [11], arsenika [12] i otrovnog bilja (bobice tisovine -Taxus cuspidate) [13].…”

Section: Uvodunclassified

Wide complex tachycardia in xenobiotic poisoning

Uzelac¹,

Đikić²

2020

NČ urgent medic Halo 194

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Wide complex tachycardia (WCT) presents on an ECG with a rate higher than 100 beats per minute and the QRS complex width of over 120ms. The usual classification of wide complex tachycardia includes ventricular tachycardia and supraventricular tachycardia with aberration, but they can also be the result of the effects of metabolic and/or toxic agents. A xenobiotic is a chemical substance that is present in an organism but is not produced within the organism or expected to be there. That also includes substances that are present within the organism in much higher concentrations than usual. For people, various drugs are also considered to be xenobiotics. One type of irregularity caused by xenobiotic poisoning is based on cardiomyocyte sodium channel blockade, responsible for the phase 0 rapid depolarization of action potentials. Certain groups of drugs can cause the WCT as a result of a repolarization disorder and prolonging of the QTc interval. Treating WCT as a result of xenobiotic poisoning depends primarily on the type of tachycardia and the disorder that caused it. Early recognition and adequate treatment are of the utmost importance for a favourable outcome.

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