2016
DOI: 10.1002/bmc.3811
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An LC–MS/MS method for simultaneous determination of 1,5‐dicaffeoylquinic acid and 1‐O‐acetylbritannilactone in rat plasma and its application to a pharmacokinetic study

Abstract: A selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous quantitative determination of 1,5-dicaffeoylquinic acid (1,5-DCQA) and 1-O-acetylbritannilactone (1-O-ABL) in rat plasma. Chromatographic separation was performed on a Zorbax Eclipse XDB-C column using isocratic mobile phase consisting of methanol-water-formic acid (70:30:0.1, v/v/v) at a flow rate of 0.25 mL/min. The detection was achieved using a triple-quadrupole tandem MS in selecte… Show more

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Cited by 4 publications
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“…This deduction was verified by the MS 2 ions at m/z 353.0882 (C 16 H 18 O 9 ) and 173.0401 (C 7 H 10 O 5 ) in negative mode. Thus, peak 30 was delineated as dicaffeoylquinic acid [40].…”
Section: Chlorogenic Acidsmentioning
confidence: 99%
“…This deduction was verified by the MS 2 ions at m/z 353.0882 (C 16 H 18 O 9 ) and 173.0401 (C 7 H 10 O 5 ) in negative mode. Thus, peak 30 was delineated as dicaffeoylquinic acid [40].…”
Section: Chlorogenic Acidsmentioning
confidence: 99%