“…There are a variety of biochemical reactions in which vitamin C plays a part, a large number of physiological processes that are consequently influenced, and a large number of clinical effects of vitamin C that have been observed in controlled trials [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. Given this, and the evidence for low vitamin C levels and increased metabolism of vitamin C in critically ill patients [90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105], it seemed reasonable to examine whether vitamin C influences practical outcomes, such as the length of ICU stay and the duration of mechanical ventilation without any restrictions on specific medical conditions.…”