An observed serving dose may not be necessary following a standard divided-dose FPIES oral food challenge

Guenther, Mariam W.; Crain, Maria; Parrish, Christopher; Bird, J. Andrew

doi:10.1016/j.jaip.2019.10.041

Cited by 10 publications

(2 citation statements)

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“…38,40 This has led to particular weaning A variety of other protocols for OFC have been published, differing in amount and number of doses and timing between the administered dose. 12,14,20,60,[68][69][70][71][72][73] Since the different OFC protocols have not been studied or compared systematically, it is at the supervising physician's judgement to adopt the protocol that best suits the patient's characteristics. 30 The timing and severity of previous reactions, as well as the amount of food ingested, should be considered when tai-…”

Section: F I G U R E 2 Diagnostic Algorithm For Acute and Chronic Fpimentioning

confidence: 99%

'Diagnosing food protein‐induced enterocolitis syndrome'

Barni

Vazquez‐Ortiz

Giovannini

et al. 2020

Clin Experimental Allergy

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Food protein-induced enterocolitis syndrome is still a mysterious disease, pathogenically poorly characterized, although the first FPIES case has been described in 1967. Mainly, food protein-induced enterocolitis syndrome diagnosis is based on clinical history. The oral food challenge remains the gold standard to confirm the diagnosis, especially in particular situations. Although there are no diagnostic laboratory or imaging tests which are specific for diagnosis, they could, however, sometimes be helpful to rule out clinical conditions which are similar to food protein-induced enterocolitis syndrome reactions. The purpose of this review is to define the clinical features of FPIES and to summarize the current available tools for the diagnosis of FPIES. This review is intended to be a practical guide for the clinician facing a patient with food protein-induced enterocolitis syndrome avoiding delayed diagnosis with unnecessary laboratory tests and detrimental treatments. Moreover, it highlights the unmet needs in diagnosis that require urgent attention from the scientific community to improve the management of patients with FPIES.

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Section: F I G U R E 2 Diagnostic Algorithm For Acute and Chronic Fpimentioning

confidence: 99%

'Diagnosing food protein‐induced enterocolitis syndrome'

Barni

Vazquez‐Ortiz

Giovannini

et al. 2020

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…Most large-scale population studies of FPIES have been based on data without an oral food challenge (OFC)-validated diagnosis. 1 , 6 , 7 , 8 , 9 Although several studies have investigated the positivity rate of OFC for FPIES (which ranged from 10% to 35%), 8 , 10 , 11 these studies included OFCs for assessing the development of tolerance but not OFCs for the diagnosis. A recent study also reported the results of as many as 11 of 21 (52%) diagnostic OFCs for FPIES as negative.…”

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confidence: 99%