An octimibate derivative, Oxa17, enhances cholesterol efflux and exerts anti-inflammatory and atheroprotective effects in experimental atherosclerosis

Tsui, Pi-Fen; Lien, Chih-Feng; Lin, Feng‐Yen; Tsai, Chien‐Sung; Tsai, Min‐Chien; Lin, Chin‐Sheng

doi:10.1016/j.bcp.2021.114581

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Anti-inflammatory Treatment Of As1

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2024

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“…This suggests that plaque stability can be improved by reducing macrophage accumulation and reducing the size of the necrotic core. [ 128 ] To test the role of anti-inflammatory therapy in AS, Ridker et al . [ 129 ] conducted a randomized, double-blind, controlled trial.…”

Section: Anti-inflammatory Treatment Of Asmentioning

confidence: 99%

Inflammatory factors driving atherosclerotic plaque progression new insights

Song

Bie

Feng

et al. 2022

Journal of Translational Internal Medicine

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Coronary atherosclerosis is a chronic inflammatory disease that can lead to varying degrees of blood flow obstruction and a common pathophysiological basis of cardiovascular disease. Inflammatory factors run through the whole process of atherosclerotic lesions. Macrophages, T cells, and neutrophils play important roles in the process of atherosclerotic inflammation. Considering the evolutionary characteristics, atherosclerosis can be divided into different stages as early atherosclerotic plaque, plaque formation stage, and plaque rupture stage. In this paper, the changes in inflammatory cells at different stages of lesions and their related mechanisms are discussed, which can provide new insights from a clinical to bench perspective for atherosclerosis me chanism.

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Section: Anti-inflammatory Treatment Of Asmentioning

confidence: 99%