An oleuropein-based dietary supplement improves joint functionality in older people with high knee joint pain

Horcajada, M-N.; Beaumont, Marc; Sauvageot, Nicolas; Poquet, Laure; Saboundjian, M; Hick, Anne-Christine; Costes, Bérénice; Garcia, Laetitia; Henrotin, Yves

doi:10.1016/j.joca.2020.02.739

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“…Oleuropein has shown high stability during digestion, while its glycosidated form reaches the colon and is transformed into a wide range of products due to microbial fermentation [ 204 , 205 ], mostly into its deglycosylated form and hydroxytyrosol [ 206 ]. Some urinary metabolic derivatives of oleuropein have been highlighted, such as oleuropein aglycone, hydroxytyrosol, homovanillyl alcohol, and an isomer of homovanillyl alcohol [ 207 ]. Although there are many published data, oleuropein is insufficiently studied in terms of metabolites found in various organs of the human body.…”

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

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Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.

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