An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

Okletey, Joshua; Angelis, Dimitrios; Jones, Tia M.; Montagna, Cristina; Spiliotis, Elias T.

doi:10.1016/j.celrep.2023.112893

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…Central to understanding this is the appreciation of two aspects: first, tumor microenvironment (TME) is full of mechanical stimuli, including solid stress, fluid stress, substrate stiffness and topological architectures, which are usually oscillated and curial for tumor progression; [ 343 ] second, numerous oncogenic factors have the potential to alter the mechanical properties of cells and tissues as well as their ability to sense mechanical stimuli. [ 344 , 345 ]…”

Section: Mechanotransduction In Diseasesmentioning

confidence: 99%

A Hierarchical Mechanotransduction System: From Macro to Micro

Cao,

Tian,

Tian

et al. 2023

Advanced Science

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Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating macroscopic and microscopic dynamics and functionalities. However, the actions and mechanisms of mechanotransduction across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to the whole‐body level, have not been yet comprehensively documented. Herein, the biological roles and operational mechanisms of mechanotransduction from macro to micro are revisited, with a focus on the orchestrations across diverse hierarchies. The implications, applications, and challenges of mechanotransduction in human diseases are also summarized and discussed. Together, this knowledge from a hierarchical perspective has the potential to refresh insights into mechanotransduction regulation and disease pathogenesis and therapy, and ultimately revolutionize the prevention, diagnosis, and treatment of human diseases.

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Section: Mechanotransduction In Diseasesmentioning

confidence: 99%

A Hierarchical Mechanotransduction System: From Macro to Micro

Cao,

Tian,

Tian

et al. 2023

Advanced Science

View full text Add to dashboard Cite

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SEPT9_i1 and Septin Dynamics in Oncogenesis and Cancer Treatment

Jędrzejczak,

Saramowicz,

Kuś

et al. 2024

Biomolecules

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Despite significant advancements in the field of oncology, cancers still pose one of the greatest challenges of modern healthcare. Given the cytoskeleton’s pivotal role in regulating mechanisms critical to cancer development, further studies of the cytoskeletal elements could yield new practical applications. Septins represent a group of relatively well-conserved GTP-binding proteins that constitute the fourth component of the cytoskeleton. Septin 9 (SEPT9) has been linked to a diverse spectrum of malignancies and appears to be the most notable septin member in that category. SEPT9 constitutes a biomarker of colorectal cancer (CRC) and has been positively correlated with a high clinical stage in breast cancer, cervical cancer, and head and neck squamous cell carcinoma. SEPT9_i1 represents the most extensively studied isoform of SEPT9, which substantially contributes to carcinogenesis, metastasis, and treatment resistance. Nevertheless, the mechanistic basis of SEPT9_i1 oncogenicity remains to be fully elucidated. In this review, we highlight SEPT9’s and SEPT9_i1’s structures and interactions with Hypoxia Inducible Factor α (HIF-1 α) and C-Jun N-Terminal Kinase (JNK), as well as discuss SEPT9_i1’s contribution to aneuploidy, cell invasiveness, and taxane resistance—key phenomena in the progression of malignancies. Finally, we emphasize forchlorfenuron and other septin inhibitors as potential chemotherapeutics and migrastatics.

show abstract

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

Cited by 2 publications

References 86 publications

A Hierarchical Mechanotransduction System: From Macro to Micro

A Hierarchical Mechanotransduction System: From Macro to Micro

SEPT9_i1 and Septin Dynamics in Oncogenesis and Cancer Treatment

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