An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo

Rath, Namita; Kar, Hemanta Kumar; Sabhnani, Sunil

doi:10.4103/0378-6323.42905

Cited by 64 publications

(20 citation statements)

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“…Subsequently, few trials on the use of OMP therapy in vitiligo have been published by other researchers with similar results (Table 3). [13][14][15][16][17][18][19][20] The present study showed good efficacy of low-dose dexamethasone OMP in controlling disease activity, with more than 90% of patients achieving an arrest of disease activity. When the duration of therapy was increased to 9 months in patients not showing an adequate response, the success rate approached 95%.…”

Section: Discussionmentioning

confidence: 94%

Low-Dose Oral Mini-Pulse Dexamethasone Therapy in Progressive Unstable Vitiligo

2013

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Section: Discussionmentioning

confidence: 94%

Low-Dose Oral Mini-Pulse Dexamethasone Therapy in Progressive Unstable Vitiligo

2013

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“…However, we combined NBUVB with oral MPD mini-pulse therapy with the aim of maximizing control and repigmentation of vitiligo. In 2008, Rath et al [22] published a study comparing the efficacy of oral mini-pulse therapy alone or combined with PUVA, broad-band UVB and NBUVB in generalized vitiligo. In their study, marked improvement was observed at 3 months in 37% of patients having received NBUVB plus oral mini-pulse therapy, 8% of patients having received broad-band UVB plus oral mini-pulse therapy, 18.4% of patients having received PUVA plus oral mini-pulse therapy and 5% of patients having received oral mini-pulse therapy alone.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

et al. 2015

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Background: Systemic corticosteroids have been used to arrest the progression of vitiligo. However, side effects have been a constant issue. Objective: We evaluated the clinical efficacy and side effect of oral methylprednisolone (MPD) mini-pulse therapy combined with narrow-band UVB (NBUVB) for adults with non-segmental vitiligo retrospectively. Methods: 32 patients with extensive and/or spreading vitiligo received 0.5 mg/kg MPD on 2 consecutive days per week with NBUVB therapy for at least 3 months. Results: All of the 32 patients (100%) showed progression arrest within 12 weeks. Nineteen out of 32 patients (59.4%) presented repigmentation on more than 25% of lesions. Thirteen patients (40.6%) achieved satisfactory repigmentation in more than 50% of lesions. Only 2 patients discontinued the medication due to gastrointestinal trouble. Conclusion: Oral MPD mini-pulse therapy combined with NBUVB appears effective in arresting vitiligo progression and rapidly inducing repigmentation with minimal side effects.

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“…In vitiligo, topical corticosteroids are the first-line treatment in the extra-facial areas (barring intertriginous and genital sites) [153]. Pulse therapy (2 consecutive days/week) with betamethasone 0.1 mg/kg for 3 months, followed by tapering of the dose by 1 mg every month over the following 3months, is a possible therapeutic option in cases of progressive generalized disease [154].…”

Section: Dermatologic Disordersmentioning

confidence: 99%

Clinical Use and Molecular Action of Corticosteroids in the Pediatric Age

Ferrara

Petrillo

Giani

et al. 2019

IJMS

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Corticosteroids are the mainstay of therapy for many pediatric disorders and sometimes are life-saving. Both endogenous and synthetic derivatives diffuse across the cell membrane and, by binding to their cognate glucocorticoid receptor, modulate a variety of physiological functions, such as glucose metabolism, immune homeostasis, organ development, and the endocrine system. However, despite their proved and known efficacy, corticosteroids show a lot of side effects, among which growth retardation is of particular concern and specific for pediatric age. The aim of this review is to discuss the mechanism of action of corticosteroids, and how their genomic effects have both beneficial and adverse consequences. We will focus on the use of corticosteroids in different pediatric subspecialties and most common diseases, analyzing the most recent evidence.

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An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo

Cited by 64 publications

References 0 publications

Low-Dose Oral Mini-Pulse Dexamethasone Therapy in Progressive Unstable Vitiligo

Low-Dose Oral Mini-Pulse Dexamethasone Therapy in Progressive Unstable Vitiligo

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

Clinical Use and Molecular Action of Corticosteroids in the Pediatric Age

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