An optoelectronic flow-through detectors for active ingredients determination in the pharmaceutical formulations

Jeber, Jalal N.

doi:10.1016/j.jpba.2021.114128

Cited by 11 publications

(8 citation statements)

References 68 publications

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“…They can also be easily automated, are less prone to contamination, and use relatively fewer reagents and sample material. [16,17] Given the significant decreases in waste generation compared to previous procedures, [18,19] they are environmentally safer. [20][21][22] Numerous spectrophotometric techniques based on colourimetric reactions have been described for the detection of doxycycline hyclate in pharmaceutical preparations and biological fluids.…”

Section: Introductionmentioning

confidence: 99%

“…Methodologies for flow injection analysis (FIA) provide a variety of important advantages, such as simplicity, cheap analysis costs, large sample rates, high accuracy, and the capacity to investigate the kinetics of certain processes. They can also be easily automated, are less prone to contamination, and use relatively fewer reagents and sample material [16,17] . Given the significant decreases in waste generation compared to previous procedures, [18,19] they are environmentally safer [20–22] .…”

Section: Introductionmentioning

confidence: 99%

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Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Abdulghani

Hassan

2023

ChemistrySelect

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Doxycycline hyclate is an antibiotic drug with a broad‐spectrum activity against a variety of gram‐positive and gram‐negative bacteria and is frequently used as a pharmacological agent and as an effector molecule in an inducible gene expression system. A sensitive, reliable and fast spectrophotometric method for the determination of doxycycline hyclate in pure and pharmaceutical formulations has been developed using flow injection analysis (FIA) and batch procedures. The proposed method is based on the reaction between the chromogenic reagent (V4+) and doxycycline hyclate in a neutral medium, resulting in the formation of a yellow compound that shows maximum absorbance at 396 nm. In a batch procedure, the proposed method was validated over the concentration range of 1.0–80 μg mL−1 with a sampling frequency of 30/h, and commercial pharmaceutical samples were successfully determined. The proposed method was successfully adapted with an FIA system where the peak heights are proportionally connected to doxycycline hyclate over the concentration range of 25–400 μg mL−1 with a sampling frequency of 50/h. The limits of detection (LOD) and quantification (LOQ) were 0.9 and 10.44 μg mL−1 and 3.01 and 34.81 μg mL−1 for batch and FIA respectively. The samples were submitted to an HPLC analysis, and the outcomes demonstrated excellent agreement with the suggested procedures. The adopted FIA procedure allows fast monitoring of doxycycline hyclate in pharmaceutical formulations and it can be used for quality control purposes during the production processes of doxycycline hyclate.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Abdulghani

Hassan

2023

ChemistrySelect

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“…Therefore, combining these factors with chemiluminescence (CL) is extremely attractive. [27][28][29] In this paper, it is reported that a CL signal is generated when Cr(III) is reacted with diethyl amino phenyl hydrazine (DEAPH) in the presence of hydrogen peroxide. However, under the same experimental conditions, Cr(VI) does not react and does not show any CL behaviour.…”

Section: Introductionmentioning

confidence: 99%

Online column preconcentration for speciation and selective determination of Cr(III) in natural water samples using flow injection with chemiluminescence detection

Jasim

Kamel²,

Al-Awadi

et al. 2023

Luminescence

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A simple, rapid, sensitive and inexpensive approach is described in this work based on a combination of solid‐phase extraction of 8‐hydroxyquinoline (8HQ), for speciation and preconcentration of Cr(III) and Cr(VI) in river water, and the direct determination of these species using a flow injection system with chemiluminescence detection (FI–CL) and a 4‐diethylamino phenyl hydrazine (DEAPH)–hydrogen peroxide system. At different pH, the two forms of chromium [Cr(III) and Cr(VI)] have different exchange capacities for 8HQ, therefore two columns were constructed; the pH of column 1 was adjusted to pH 3 for retaining Cr(III) and column 2 was adjusted to pH 1 for retaining of Cr(VI). The sorbed Cr(III) and Cr(VI) species were eluted from columns using 3.0 ml of 0.1 N of HCl and 3.0 ml of 0.1 N of NaOH, respectively. The flow injection–chemiluminescence (FI–CL) method is based on light emitted due to the oxidation of DEAPH by the H2O2 in the presence of Cr(III), which catalyzes the reaction. The flow cell is a transparent coiled tube made from glass (2.0 × 4.0, inner and outer diameter) and located close to the photodetector. The flow parameters: flow rate, sample volume, flow cell length, and distance to the CL detector were studied and optimized. Under optimum flow conditions, the Cr(III) concentration can be determined over the range 5–350 μg L−1 with a limit of detection of 1.2 μg L−1, as the Cr(III) concentration is proportional to the intensity of the CL signal. The relative standard deviations (%) for 10 and 50 μg L−1 Cr(III) were 1.2% and 3.2%, respectively. The effects of Al(III), Cd(II), Zn(II), Hg(II), Pb(II), Co(II), Cu(II), Ni(II), Mn(II), Ca(II), and Fe(III) were investigated. The proposed method is highly selective and sensitive, enabling a rapid determination of the Cr(III) amount in the presence of other interfering metals. Finally, the FI–CL method was examined in five river water samples with excellent recoveries.

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“…[23] Flow injection-spectrophotometric technique is the most commonly used for determination of active pharmaceutical ingredients in their formulations, using this technique for pesticide determination is the most required in the field of pesticide determination. [24][25][26][27][28][29][30][31][32][33][34][35][36] To the best of our knowledge, the flow injection technique with indirect photometric detection for the determination of fosetyl-Al in commercial samples of protection products has not been applied. The main aim of the present study is to develop and validate a rapid, simple and reliable analytical method for the assay of fosetyl-Al in pesticide formulations that uses the most common available instrument in the laboratories which is (Photometry).…”

Section: Introductionmentioning

confidence: 99%

A Continuous Flow Injection/Indirect Photometric Method for the Detection of Fosetyl Aluminum in Commercial Pesticide Formulations

Sadiq

Hammood

2022

ChemistrySelect

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Because of their Physico-chemical characteristics and its composition, the development of new specific analytical methodologies to determine some highly polar pesticides are required. The reported methods demand long analysis time, expensive instruments and prior extraction of pesticide for detection. The current work presents a new flow injection analysis method combined with indirect photometric detection for the determination of Fosetyl-Aluminum (Fosetyl-Al) in commercial formulations, with rapid and highly accurate determination involving only construction of manifold system combined with photometric detector without need some of the pre-treatments to the sample before the analysis such as extraction or separation. The proposed method is based on the reaction between the Fosetyl-Al with the colorimetric reagent (Aluminon dye) in an aqueous medium of sodium nitrite resulting in the formation of a red complex and its absorbance is measured using the photometric detector. The proposed method included optimization of several parameters such as sodium nitrite concentration, flow rate, sample volume, Aluminon dye concentration, mixing coil and light intensity. The linear range of the detector response was in the range of 0.005-1.8 mmol/L for the sample with r (coefficient of determination) 0.9909, R 2 (correlation coefficient) 0.9954 at 95 % and 0.0041 mmol/L as a limit of detection. The relative standard deviation was less than 1.5 % for 0.005 mmol/L of the analyte (n = 11). The proposed method was validated and applied successfully for the determination of Fosetyl-Al in commercial formulations and can be used as an alternative method for quality control assessment.

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An optoelectronic flow-through detectors for active ingredients determination in the pharmaceutical formulations

Cited by 11 publications

References 68 publications

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Online column preconcentration for speciation and selective determination of Cr(III) in natural water samples using flow injection with chemiluminescence detection

A Continuous Flow Injection/Indirect Photometric Method for the Detection of Fosetyl Aluminum in Commercial Pesticide Formulations

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