An overview of ascorbic acid biochemistry

Abstract

Ascorbic acid (vitamin C) is a water-soluble micronutrient required for multiple biological functions. Ascorbic acid is a cofactor for several enzymes participating in the post

Effects of Graded Level of Dietary L-Ascorbyl-2-Polyphosphate on Growth Performance and Some Hematological Indices of Juvenile Mahseer (Tor putitora)

“…Means are followed by different letter within the column are significantly different (P < 0.05). (ANOVA followed by LSD test) (Aysun, 2009), amidation of peptide hormones (Jimenez-Fernandez et al, 2012), metabolism of iron (James, 2001) and immunity (Anbarasu and Chandran, 2001;Ai et al, 2006) or by acting as a resistant modulator (Tewary and Patra, 2008;Eo and Lee, 2008).…”

“…Vitamins and minerals are the micronutrient, although require in small quantities but are essential for normal metabolism of all vertebrates including fish and their deficiency in the diet can cause diseases. Among them vitamin C is an important micronutrient that plays significant role in the growth (Ai et al, 2006;Eo and Lee, 2008;Miar et al, 2013), reproduction (Dabrowski and Ciereszko, 2001;Farahi, 2011), biosynthesis of various neuropeptides (Eipper et al, 1993), maintenance of many enzymes in a reduced state (Aysun, 2009), healing of wounds (Tewary and Patra, 2008;Campos et al, 2008) and immune reactions (Anbarasu and Chandran, 2001; Kumari and Sahoo, 2005;Ai et al, 2006;Eo and Lee, 2008). Beside these also act as an antioxidant (Murmu and Shrivastava, 2011) and involve in the removal of hydrogen peroxide and deactivation of superoxide radicals.…”

“…However, deficiency of vitamin C cause spinal deformation, retarded growth, caudal fin erosion, lordosis and scoliosis (Lewis-McCrea and Lall, 2010), impaired wound healing (Campos et al, 2008), anemia (Adham et al, 2000), liver atrophy (Wang et al, 2003), poor collagen formation (Aysun, 2009), increased susceptibility to bacterial diseases (Ai et al, 2006), lower survival rates (Adham et al, 2000;Wang et al, 2003) in finfish, while black death disease in shrimp (Lightner et al, 2009).…”

Non-Enzymatic Natural Reactive Oxygen Scavengers (Ros): A Review on Structures and Mode of Action

“…to Fe from elemental or non-heme iron sources (figure 6). On the other hand, it behaves as a prooxidant molecule and leads to the generation of hydroxyl freeradicals' species that may damage protein, lipid, and nucleic acid through Fenton reaction (22).The toxicity of vitamin C is very is low, although due to higher doses, oxalate calculi may appear in kidney. It is estimated that about 60 mg of vitamin C could potentially form up to 30 mg oxalate per day (19).…”

Calyx Juice of &lt;i&gt;Hibiscus sabdariffa Linn&lt;/i&gt; (Malvaceae): A Possible Therapeutic Supplement to Antiretroviral Drugs

“…Much research work has documented the mechanism of this induced apoptosis on three major biological molecules: DNA, proteins and lipids. For the membrane lipids, the hydroxyl radical initiates chain reactions at the level of polyunsaturated fatty acids by first abstracting a hydrogen atom from the side chain of a polyunsaturated fatty acid [23]. The chain reactions lead to the formation of lipid free radicals and peroxides, which invariably damages the molecular structure of membrane lipids, including those of the defense cells [14].…”