An Overview of Biological Importance, Pharmacological Aspects, and Analytical Techniques of Bavachin from Psoralea corylifolia Linn.

Abstract

Background: Psoralea corylifolia Linn belongs to Leguminosae family is commonly known as ‘Bakuchi’ in Ayurvedic system of medicine. P. corylifolia is an important medicinal herb used for the treatment of Leucoderma, psoriasis and leprosy. P. corylifolia seed contain psoralen, psoralidin, isopsoralen, neobavaisoflavone, corylin, bavachin, and bavachalcone. P. corylifolia has been used for the treatment of asthma, vitiligo, nephritis, calvities and cough. Bavachin is a pure phytochemical, found to be present in the seeds and fruit of P. corylifolia. Methods: In order to know the medicinal properties and therapeutic benefit of bavachin in the medicine, numerous scientific research data have been collected from different literature sources and analyzed. Medicinal importance and pharmacological activities of bavachin has been investigated through literature data analysis of different scientific research works. Scientific research data has been collected from databases such as PubMed, Google, Google Scholar, Science Direct, and Scopus using words Psoralea corylifolia and bavachin. Further maximum scientific article of bavachin with respect to its pharmacological activities, medicinal importance, and analytical data of has been collected from these databases and presented here with proper citation. Results: Data analysis of scientific research works of bavachin revealed the biological importance of bavachin in the medicine. Bavachin showed anti-inflammatory, anticancer, anti-bacterial, lipid-lowering and cholesterol-reducing properties in the medicine. Bavachin has multiple pharmacological activities including platelet aggregation, α-glucosidase activities and antibacterial potential. Bavachin has a potential estrogen supplement for estrogen replacement therapy. Present work summarized biological potential of bavachin on inflammatory disorders, articular cartilage degeneration, cardiovascular disease, hyperglycemia, Parkinson's disease, Alzheimer's disease, apoptosis, melanin synthesis, estrogen Receptor, UDP-glucuronosyltransferase 1A1 and various form of pathogenic infection. Analytical data revealed the significance of an HPLC-UV, HPLC, HPLC-ECD, HPLC-DAD, IT-MS, HPLC, HPLC/TOF-MS, LC-MS/MS and ILUAE techniques for separation, identification and quantification of bavachin in different samples. Conclusion: Literature data analysis revealed the biological importance and therapeutic potential of bavachin in the medicine for the treatment of various form of human disorders.