In this study we aimed to evaluate the relationship among the quality of life, functional capacity, physical activity and performance levels of individuals with chronic venous disease (CVD). Methods: 210 individuals with CVD grade I-V according to the CEAP classification were included in the study. Functional capacity of individuals was evaluated by the 6-minute walk test (6MWT) and heart rate, blood pressure and oxygen saturations were assessed before and after the 6MWT. Physical activity level International Physical Activity Questionnaire (IPAQ), performance level sit-to-stand test and Quality of life VEnous INsufficiency Epidemiologic and Economic Study on Quality of Life Questionnaire (VEINES-QoL). The data for the study was calculated using the SPSS 20.0 package program. Results: The study consisted of 143 (%68,1) female, 67 (%31,9) male individuals. The average of age was 39,2±10,1 and body mass index (BMI) was 27,9±6,32. Quality of life has significant positive and low correlation with performance level (r = 0.161 p <0.05), physical activity (r = 0.178 p <0.05) and functional capacity (r = 0.171 p <0.05). In addition, there was a significant positive and moderate correlation in functional capacity with performance (r = 0.521 p <0.001). Conclusions: CVD has been reported as an important health problem that negatively affects the life quality of individuals (1). In individuals with chronic venous disease, the quality of life decreases when physical activity, functional capacity and performance are low. Considering the negative impact on public health due to high prevalence, we think that the data obtained in more cases can explain the evaluations in this study better.