An Overview of the Use of Nanoparticles in Vaccine Development

Lozano, Daniel; Larraga, Vicente; Vallet‐Regí, María; Manzano, Miguel

doi:10.3390/nano13121828

Cited by 15 publications

(5 citation statements)

References 124 publications

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“…In addition, tailored nanoparticles provide the potential to provide enhanced advantages as they can be intentionally created to interact with or evade the immune system selectively. The aforementioned characteristics have facilitated the emergence and advancement of the discipline known as nanovaccines. − Vaccines are integrated into nanoparticles via conjugation, encapsulation, and adsorption. This process safeguards the native antigen against proteolytic degradation and enhances the transportation of antigens to antigen-presenting cells (APCs).…”

Section: Strategies and Challenges Involved In Manufacturing Of A Nan...mentioning

confidence: 99%

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Gholap,

Gupta,

Kamandar

et al. 2023

ACS Biomater. Sci. Eng.

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Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid and nonlipid formulations, exhibit considerable advantages over traditional vaccine techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, and the potential for codelivery with adjuvants or immune modulators. This review provides a comprehensive overview of the latest advancements and applications of lipid and non-lipid-based nanovaccines in current vaccination strategies for immunization. The review commences by outlining the fundamental concepts underlying lipid and nonlipid nanovaccine design before delving into the diverse components and production processes employed in their development. Subsequently, a comparative analysis of various nanocarriers is presented, elucidating their distinct physicochemical characteristics and impact on the immune response, along with preclinical and clinical studies. The discussion also highlights how nanotechnology enables the possibility of personalized and combined vaccination techniques, facilitating the creation of tailored nanovaccines to meet the individual patient needs. The ethical aspects concerning the use of nanovaccines, as well as potential safety concerns and public perception, are also addressed. The study underscores the gaps and challenges that must be overcome before adopting nanovaccines in clinical practice. This comprehensive analysis offers vital new insights into lipid and nonlipid nanovaccine status. It emphasizes the significance of continuous research, collaboration among interdisciplinary experts, and regulatory measures to fully unlock the potential of nanotechnology in enhancing immunization and ensuring a healthier, more resilient society.

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Section: Strategies and Challenges Involved In Manufacturing Of A Nan...mentioning

confidence: 99%

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Gholap,

Gupta,

Kamandar

et al. 2023

ACS Biomater. Sci. Eng.

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show abstract

“…By improving antigen processing and its presentation to antigen-presenting cells (APCs), this enhances the activation of CD4 + and CD8 + cells. This recent advance in vaccine technology holds promise for eliciting protective immune responses against the virus [96].…”

Section: Nanoparticles In Vaccines and Risk Assessmentmentioning

confidence: 99%

“…A crucial role in enhancing the effectiveness of vaccines is played by delivery systems based on nanoformulations. By tailoring nanoencapsulation, vaccines can be delivered with precision and stability [96].…”

Section: Nanoparticles In Vaccines and Risk Assessmentmentioning

confidence: 99%

Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control

Araste,

Bakker,

Zandieh-Doulabi

2023

J Nanopart Res

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The ongoing battle against viral infections highlighted so recently by the COVID-19 pandemic demonstrates the need to develop new approaches using nanotechnology in antiviral strategies. Nanoparticles have emerged as promising tools in the fight against viral outbreaks, offering various options for application such as biosensors, vaccine nanoparticles, disinfectants, and functionalized nanoparticles. In this comprehensive review, we evaluate the role of nanoparticles in pandemic control, exploring their potential applications, benefits, and associated risks. We first discuss the importance of nanotechnology in viral outbreak management, particularly in vaccine development. Although lipid nanoparticles play a crucial role in mRNA vaccines, there are concerns about their potential side effects. Although functionalization of protective face masks using metallic nanoparticles has emerged as a sustainable alternative to disposable masks, reducing waste production and enhancing virus filtration, improper disposal of such masks leads to environmental contamination and potential ecological harm. Second, we address the potential adverse effects associated with nanoparticle-based vaccines containing polyethylene glycol and other vaccine components, which trigger autoimmune diseases and alter menstrual cycles. To manage outbreaks effectively, we must minimize such potential risks and environmental impacts. Thus, when developing effective strategies for future pandemic control, it is crucial to understand the advantages and challenges associated with nanoparticle usage.

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“…The application of nanotechnology in vaccine design is an active area of research, with ongoing efforts to translate these innovative approaches into real-world vaccine products. Continued advancements in nanomaterials, formulation development, and clinical testing will be crucial for unlocking the full potential of nanotechnology in vaccine design and optimization [ 5 , 6 , 7 ]. In this review article, we evaluate the advantages and disadvantages of graphene materials in vaccine design.…”

Section: Introductionmentioning

confidence: 99%

A Narrative Review on the Promising Potential of Graphene in Vaccine Design: Evaluating the Benefits and Drawbacks of Carbon Nanoplates in Nanovaccine Production

Zare-Zardini,

Saberian,

Jenča

et al. 2024

Vaccines

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Graphene, a two-dimensional material consisting of a single layer of carbon atoms arranged in a honeycomb lattice, has shown great potential in various fields, including biomedicine. When it comes to vaccine development, graphene can offer several advantages due to its unique properties. Potential applications of graphene in vaccine development include improved vaccine delivery, adjuvant properties, improved vaccine stability, improved immune response, and biosensing capabilities. Although graphene offers many potential benefits in vaccine development, there are also some drawbacks and challenges associated with its use. Although graphene shows promising potential for vaccine development, overcoming the challenges and limitations associated with its use is critical to realizing its full potential in the field of immunization. Further research and development efforts are needed to overcome these drawbacks and take advantage of graphene for improved vaccine formulations. In this review, we focus on the advantages and disadvantages of graphene for vaccine development.

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An Overview of the Use of Nanoparticles in Vaccine Development

Cited by 15 publications

References 124 publications

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control

A Narrative Review on the Promising Potential of Graphene in Vaccine Design: Evaluating the Benefits and Drawbacks of Carbon Nanoplates in Nanovaccine Production

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