An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances

Zeinali, Majid; Rezaee, Seyed Abdolrahim; Hosseinzadeh, Hossein

doi:10.1016/j.biopha.2017.06.003

Cited by 170 publications

(109 citation statements)

References 84 publications

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“…Inflammation in metabolic diseases is a key process that must be monitored in the patients affected by these disorders, since it can trigger a metabolic crisis and the appearance of the main symptoms and sequels left in the disease. [47][48][49] Finally, a lower concentration of L-car was also observed in the patients at diagnosis that was corrected by L-car supplementation. 43,44 In this context, it is emphasized that increased pro-inflammatory cytokines can be related to an excessive production of reactive species, contributing to inflammation.…”

Section: Discussionmentioning

confidence: 84%

“…IL-6 is a mediator of the acute phase inflammation produced by T and B cells and GM-CSF is one of the cytokines that stimulate the hematopoiesis and promote the maturation of bone marrow cells in dendritic cells and monocytes. [47][48][49] Finally, a lower concentration of L-car was also observed in the patients at diagnosis that was corrected by L-car supplementation. Since L-car has important antioxidant and anti-inflammatory properties, allied to the fact that dietary L-car addition helped to decrease oxidative stress in patients affected by phenylketonuria 34 maple syrup urine disease 35 and by inherited disorders of propionate metabolism, 14 it is conceivable that L-car could totally prevent or attenuate the oxidative damage and the reduction of the antioxidant defenses encountered in our work.…”

Section: Discussionmentioning

confidence: 84%

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Oxidative damage in glutaric aciduria type I patients and the protective effects of l‐carnitine treatment

Guerreiro

Faverzani

Jacques

et al. 2018

J of Cellular Biochemistry

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The deficiency of the enzyme glutaryl-CoA dehydrogenase, known as glutaric acidemia type I (GA-I), leads to the accumulation of glutaric acid (GA) and glutarilcarnitine (C5DC) in the tissues and body fluids, unleashing important neurotoxic effects. l-carnitine (l-car) is recommended for the treatment of GA-I, aiming to induce the excretion of toxic metabolites. l-car has also demonstrated an important role as antioxidant and anti-inflammatory in some neurometabolic diseases. This study evaluated GA-I patients at diagnosis moment and treated the oxidative damage to lipids, proteins, and the inflammatory profile, as well as in vivo and in vitro DNA damage, reactive nitrogen species (RNS), and antioxidant capacity, verifying if the actual treatment with l-car (100 mg kg day ) is able to protect the organism against these processes. Significant increases of GA and C5DC were observed in GA-I patients. A deficiency of carnitine in patients before the supplementation was found. GA-I patients presented significantly increased levels of isoprostanes, di-tyrosine, urinary oxidized guanine species, and the RNS, as well as a reduced antioxidant capacity. The l-car supplementation induced beneficial effects reducing these biomarkers levels and increasing the antioxidant capacity. GA, in three different concentrations, significantly induced DNA damage in vitro, and the l-car was able to prevent this damage. Significant increases of pro-inflammatory cytokines IL-6, IL-8, GM-CSF, and TNF-α were shown in patients. Thus, the beneficial effects of l-car presented in the treatment of GA-I are due not only by increasing the excretion of accumulated toxic metabolites, but also by preventing oxidative damage.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

Oxidative damage in glutaric aciduria type I patients and the protective effects of l‐carnitine treatment

Guerreiro

Faverzani

Jacques

et al. 2018

J of Cellular Biochemistry

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“…2010;Liu, Li, Wang, Guo, & Wen, 2014;Rauf et al, 2015;Zeinali, Rezaee, & Hosseinzadeh, 2017) Bae, Lee, and Kim (2011). suggested that CR is an anti-allergic inflammatory agent because of inhibited to releasing of histamine via modulation of intracellular calcium and pro-inflammatory cytokines (IL-4, IL-6, IL-1β, and TNF-α) via NF-κB and caspase-1 Bai et al (2013).…”

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confidence: 99%

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

et al. 2020

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Chrysin (CR) is a flavone found in propolis and many plants. Lipopolysaccharide (LPS) is a component of the cell wall of gram‐negative bacteria that causes sepsis. The purpose of this study was to investigate the effects of CR on LPS‐induced sepsis in rats. LPS intraperitoneal and a single dose and CR were given orally for 10 days. Rats were sacrificed, blood samples were taken, liver, lung, and kidney tissues were dissected, homogenized, and histopathological analysis was carried out. When CR groups compared to sepsis group, CR significantly decreased the serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin‐1 beta (IL‐1β), interleukin‐10 (IL‐10), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and levels of malondialdehyde (MDA) in tissues. CR also increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) in tissues. Histopathological findings were consistent with biochemical findings. Conclusion, CR could reduce the oxidative stress markers and cytokines in sepsis. Practical applications Our approach is to determine the antioxidant and anti‐inflammatory effects of chrysin, known as a flavolonoid, which are found in many plants and foods such as honey and propolis. In this study, experimental sepsis model was created using LPS. According to the results of the study, CR can attribute to the ameliorating of oxidative damage in tissues (lung, liver, and kidney) and it can suppress the sepsis‐associated acute tissue injury via reduction of inflammation in rats. Even, CR can be used as a pharmacological agent in inflammatory diseases caused by other sources and in many cases causing oxidation.

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“…Also, they demonstrate vasorelaxant, antioxidant, antiatherogenic, and bronchodilatory activities, among others (Harborne & Williams, 2000;Tanaka & Takahashi, 2013;Torres-Piedra et al, 2011). In addition, flavonoids have been suggested as having anti-inflammatory properties, which avoid damage induced by neutrophils as the central cell in the acute inflammatory process (Zeinali, Rezaee, & Hosseinzadeh, 2017). Moreover, the anti-allergic activity of fisetin was shown to inhibit the degranulation of immunoglobulin E (IgE)/Ag-stimulated RBL-2H3 cells in a dosedependent manner (Jo & Park, 2017).…”

mentioning

confidence: 99%

Functional mechanism of tracheal relaxation, antiasthmatic, and toxicological studies of 6‐hydroxyflavone

Flores‐Flores

Estrada‐Soto

Millán‐Pacheco

et al. 2018

Drug Development Research

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Previously, we described tracheal rat rings relaxation by several flavonoids, being 6‐hydroxyflavone (6‐HOF) the most active derivative of the series. Thus, its mechanism of action was determined in an ex vivo tracheal rat ring bioassay. The anti‐asthmatic effect was assayed in in vivo OVAlbumin (OVA)‐sensitized guinea pigs. Finally, the toxicological profile of 6‐HOF was studied based on Organization of Economic Cooperation and Development guidelines with modifications. 6‐HOF–induced relaxation appears to be related with receptor‐operated calcium channel and voltage‐operated calcium channel blockade as the main mechanism of action, and also through the production of relaxant second messengers NO and cGMP. Molecular docking supports that 6‐HOF acts as calcium channel blocker and by activation of nitric oxide synthase. In addition, the in vivo anti‐asthmatic experiments demonstrate the dose‐dependent significant anti‐allergic effect of 6‐HOF induced by OVA, with best activity at 50 /kg. Finally, toxicological studies determined a LD50 > 2,000 mg/kg and, after 28 day of treatment with 6‐HOF (50 mg/kg) by intragastric route, mice did not exhibit evidence of any significant toxicity. In conclusion, experiments showed that 6‐HOF exerts significant relaxant activity through calcium channel blockade, and possibly, by NO/cGMP‐system stimulation on rat trachea, which interferes with the contraction mechanism of smooth muscle cells in the airways. In addition, the flavonoid shows potential anti‐asthmatic properties in an anti‐allergic pathway. Furthermore, because the pharmacological and safety evidence, we propose this flavonoid as lead for the development of a novel therapeutic agent for the treatment of asthma and related respiratory diseases.

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An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances

Cited by 170 publications

References 84 publications

Oxidative damage in glutaric aciduria type I patients and the protective effects of l‐carnitine treatment

Oxidative damage in glutaric aciduria type I patients and the protective effects of l‐carnitine treatment

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

Functional mechanism of tracheal relaxation, antiasthmatic, and toxicological studies of 6‐hydroxyflavone

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