An Overview on Ionic Liquids: A New Frontier for Nanopharmaceuticals

Almeida, Tânia Santos de; Caparica, Rita; Júlio, Ana; Reis, Catarina Pinto

doi:10.1007/978-3-030-44925-4_5

Cited by 6 publications

(1 citation statement)

References 127 publications

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“…There are some concerns regarding toxicity of ionic liquids; nanoparticles appear to be safer. Their conjunction holds valuable promise in improving drug stability, and consequently, their performance, as the ionic liquids can also improve thermal and chemical stability of nanoparticles [ 99 ]. On the other hand, PEGs are considered remarkably safe, a quality that makes them frequently used in cosmetic products [ 100 ].…”

Section: Approaches For Enhancing Cyt C Thermal St...mentioning

confidence: 99%

Cytochrome c in cancer therapy and prognosis

Pessoa

2022

Bioscience Reports

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Cytochrome c (cyt c) is an electron transporter of the mitochondrial respiratory chain. Upon permeabilization of the mitochondrial outer membrane, cyt c is released into the cytoplasm, where it triggers the intrinsic pathway of apoptosis. Cytoplasmic cyt c can further reach the bloodstream. Apoptosis inhibition is one of the hallmarks of cancer and its induction in tumors is a widely used therapeutic approach. Apoptosis inhibition and induction correlate with decreased and increased serum levels of cyt c, respectively. The quantification of cyt c in the serum is useful in the monitoring of patient response to chemotherapy, with potential prognosis value. Several highly sensitive biosensors have been developed for the quantification of cyt c levels in human serum. Moreover, the delivery of exogenous cyt c to the cytoplasm of cancer cells is an effective approach for inducing their apoptosis. Similarly, several protein-based and nanoparticle-based systems have been developed for the therapeutic delivery of cyt c to cancer cells. As such, cyt c is a human protein with promising value in cancer prognosis and therapy. In addition, its thermal stability can be extended through PEGylation and ionic liquid storage. These processes could contribute to enhancing its therapeutic exploitation in clinical facilities with limited refrigeration conditions. Here, I discuss these research lines and how their timely conjunction can advance cancer therapy and prognosis.

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Section: Approaches For Enhancing Cyt C Thermal St...mentioning

confidence: 99%

Cytochrome c in cancer therapy and prognosis

Pessoa

2022

Bioscience Reports

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Role of ionic liquids on stabilization of therapeutic proteins and model proteins

Guncheva

2022

Protein J

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Ionic liquid method for the extraction of lipid from microalgae biomass: a review

Motlagh

Elgharbawy

Khezri

et al. 2021

Biomass Conv. Bioref.

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Microalgae are an alternative source of renewable energy and high-value products for pharmaceutical, nutraceutical, etc., due to rich in carbohydrates, proteins, lipids, and high-density lipoproteins. Existing methods for cell disruption and extraction are costly and suffered from low proficiencies. Ionic liquids are proven to be an environmentally friendly substitute to conventional volatile organic solvents. They have been used in extracting different types of biomass , including microalgae . This article reviews the potential of ILs in extracting biomolecules, lipid , and omega-3, from microalgae biomass . The physicochemical properties of ILs, including viscosity, density, and melting point, their advantages and limitation, as well as toxicity and recyclability of ILs in lipid processing, are discussed.

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An Overview on Ionic Liquids: A New Frontier for Nanopharmaceuticals

Cited by 6 publications

References 127 publications

Cytochrome c in cancer therapy and prognosis

Cytochrome c in cancer therapy and prognosis

Role of ionic liquids on stabilization of therapeutic proteins and model proteins

Ionic liquid method for the extraction of lipid from microalgae biomass: a review

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