An Overview on Natural Polymer Based Mucoadhesive Buccal Films for Controlled Drug Delivery

Abstract

Mucoadhesion is the process where polymers attach to biological substrate or a syn to mucus or an epithelial surface. When the biological substrate is attached to a mucosal layer then this phenomenon is known as mucoadhesion. The substrate possessing bioadhesive polymer can help in drug delivery for a prolonged period of time at a specific delivery site. Mucoadhesive polymers are used to improve drug delivery by enhancing the dosage form's contact time and residence time with the mucous membrane mucoadhesion and some factors which have the ability to affect the mucoadhesive properties of a polymer. Both natural and synthetic polymers are used for the preparation of mucoadhesive buccal which can be used in mucoadhesive buccal This review is an effort to summarize the work done till date and to show the future pathway of mucoadhesive buccal films preparation using natural polymer.

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“…Typically, the buccal film formulation consists of 5-30% (w/w) of the drug. Hydrophilic drugs are either in a dissolved state or as a solid solution, while hydrophobic drugs are evenly dispersed within the buccal film 13 . The drug's release can be altered, and the desired release pattern can be achieved by incorporating therapeutic agents in milled, micronized, or nanoparticle forms.…”