An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future

Elkordy, Amal; Haj‐Ahmad, Rita; Awaad, Amani S.; Zaki, Randa Mohammed

doi:10.1016/j.jddst.2021.102459

Cited by 65 publications

(30 citation statements)

References 83 publications

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“…Medicinal plants have great significance in the health industry. Today, almost 25% of modern medicines are obtained or derived from natural sources [1][2][3]. To this end, according to a recent report by the British Broadcasting Corporation (BBC), plant-derived drugs will grow from USD 29.3 billion in 2017 to around USD 39.2 billion by 2022, with a compound annual growth rate (CAGR) of 6.1% per year for the same period.…”

Section: Introductionmentioning

confidence: 99%

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Motolinía-Alcántara

Castillo‐Araiza

Rodrı́guez-Monroy

et al. 2021

Plants

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The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to meet the increasing demand for bioactive compounds for the treatment and prevention of degenerative diseases is nowadays considered an engineering challenge due to the large number of operational factors that need to be considered during their design and scale-up. The plant cell suspension culture (CSC) has presented numerous benefits over other technologies, such as the conventional whole-plant extraction, not only for avoiding the overexploitation of plant species, but also for achieving better yields and having excellent scaling-up attributes. The selection of the bioreactor configuration depends on intrinsic cell culture properties and engineering considerations related to the effect of operating conditions on thermodynamics, kinetics, and transport phenomena, which together are essential for accomplishing the large-scale production of PDSM. To this end, this review, firstly, provides a comprehensive appraisement of PDSM, essentially those with demonstrated importance and utilization in pharmaceutical industries. Then, special attention is given to PDSM obtained out of CSC. Finally, engineering aspects related to the bioreactor configuration for CSC stating the effect of the operating conditions on kinetics and transport phenomena and, hence, on the cell viability and production of PDSM are presented accordingly. The engineering analysis of the reviewed bioreactor configurations for CSC will pave the way for future research focused on their scaling up, to produce high value-added PDSM.

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Section: Introductionmentioning

confidence: 99%

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Motolinía-Alcántara

Castillo‐Araiza

Rodrı́guez-Monroy

et al. 2021

Plants

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“…These products contain a variety of compounds that can interact with multiple targets, leading to additive and/or synergistic effects. Such effects have been widely suggested in well-documented and widely discussed scientific literature [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Achyrocline satureioides (Lam.) DC (Asteraceae) Extract-Loaded Nanoemulsions as a Promising Topical Wound Healing Delivery System: In Vitro Assessments in Human Keratinocytes (HaCaT) and HET-CAM Irritant Potential

et al. 2021

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Achyrocline satureioides (Lam.) DC Asteraceae extracts (ASEs) have been investigated for the treatment of various skin disorders. This study reports the effects of ASE-loaded nanoemulsions (NEASE) on the cellular viability, death by necrosis, and migration of immortalized human keratinocytes (HaCaT cell line), as well as the irritant potential through the hen’s egg chorioallantoic membrane test (HET-CAM). NEASE exhibited a polydispersity index above 0.12, with a droplet size of 300 nm, ζ-potential of −40 mV, and content of flavonoids close to 1 mg/mL. No cytotoxicity of the ASE was observed on HaCaT by MTT assay (up to 10 µg/mL). A significant increase of HaCaT viability was observed to NEASE (up to 5 μg/mL of flavonoids), compared to treatment with the ASE. The necrosis death evaluation demonstrated that only NEASE did not lead to cell death at all the tested concentrations. The scratch assay demonstrated that NEASE was able to increase the cell migration at low flavonoid concentrations. Finally, the HET-CAM test proved the non-irritative potential of NEASE. Overall, the results indicate the potential of the proposed formulations for topical use in wound healing, in view of their promising effects on proliferation and migration in keratinocytes, combined with an indication of the absence of cytotoxicity and non-irritating potential.

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“…In the past decade, people have been looking for new health-promoting compounds from natural sources. Among the natural sources, plants and plant products are the most important [ 1 ]. For example, the determination of antioxidant properties of plant extracts is an index of the efficacy against oxidative stress, which is associated with chronic inflammatory and degenerative diseases [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

Zengin

Mahomoodally

et al. 2021

Antioxidants

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Epilobium hirsutum is extensively used as a traditional remedy in folk medicine, especially against prostate inflammation. Therefore, we evaluated the chemical profiles and biopharmaceutical potentials of different extracts of E. hirsutum aerial parts and roots. Metabolomic, antioxidant, and enzyme inhibitory profiles were investigated. Human prostate cancer PC3 cells were exposed to the extracts to evaluate antiproliferative effects. Gene expression and bioinformatics analyses were performed to investigate anti-inflammatory mechanisms. Oenothein B and myricetin were prominent compounds in the extracts. In scavenging/reducing assays, the methanol, infusion, and methanol/water extracts exhibited similar activities. We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol/water extracts. According to bioinformatics analysis, myricetin was predicted to interact with COX-2 and TNFα. The interaction between TNFα and oxo-dihydroxy-octadecenoic acid was predicted as well. Intriguingly, the gene expression of COX-2 and TNFα was reduced in PC3 cells after exposure to methanol and methanol/water extracts. These effects were paralleled by the decreased gene expression of IL-8 and NFkB and the inhibition of PGE2 release. Therefore, the present findings suggest the potential use of E. hirsutum for the management of the burden of inflammation and oxidative stress occurring in lower urinary tract diseases, including prostatitis.

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An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future

Cited by 65 publications

References 83 publications

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Achyrocline satureioides (Lam.) DC (Asteraceae) Extract-Loaded Nanoemulsions as a Promising Topical Wound Healing Delivery System: In Vitro Assessments in Human Keratinocytes (HaCaT) and HET-CAM Irritant Potential

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

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