An overview on the relationship between endometriosis and infertility: the impact on sexuality and psychological well-being

Rosa, Valentina Lucia La; Barra, Fabio; Chiofalo, Benito; Platania, Alessio; Guardo, Federica Di; Conway, Francesca; Antonio, Silvia Di Angelo; Lin, Li

doi:10.1080/0167482x.2019.1659775

Cited by 61 publications

(40 citation statements)

References 51 publications

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“…Oxidative stress is related to increased granulosa cell apoptosis, which may account for inferior embryo quality and reduced live birth [42]. The condition of oxidative stress may be attributed to poor ovarian function, or have something to do with underlying psychological conditions [43,44].…”

Section: Discussionmentioning

confidence: 99%

Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study

et al. 2020

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Background: Women with endometriosis and previous cystectomy may respond less well to gonadotropin stimulation, which results in fewer oocytes retrieved and poor pregnancy outcomes. Choosing an appropriate protocol for such populations is essential. This study involved an analysis of the effect of different controlled ovarian stimulation (COS) protocols on the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) in women with diminished ovarian reserve (DOR) who underwent ovarian endometrioma cystectomy. Methods: A total of 342 patients that underwent IVF-ET treatment at the Beijing Obstetrics and Gynecology Hospital from January 1, 2013 to April 30, 2018 were included in this retrospective study. The patients were distributed into three groups according to the COS protocols, namely prolonged GnRH-agonist (Group A, n = 113), GnRH-antagonist (Group B, n = 121), and long GnRH-agonist (Group C, n = 108). The clinical and laboratory parameters of the three protocols were analyzed and a logistic regression of clinical pregnancy and live births was conducted. Results: There were no significant differences in the age, infertility duration, basic follicle stimulation hormone (FSH), luteinizing hormone (LH), or estradiol (E 2 ) levels as well as other baseline characteristics among groups (P > 0.05). The total gonadotrophin (Gn) dosage and duration tended to be less in the GnRH-antagonist group than in the others (P < 0.05). No significant differences were found in the implantation rate and clinical pregnancy rate among the groups, but the prolonged GnRH-agonist group showed the highest rates. In addition, no significant differences were present in the number of retrieved oocytes, oocyte fertilization rate, embryo utilization rate, live birth rate, abortion rate, ectopic pregnancy rate, or multiple pregnancy rate in the three groups (P > 0.05). Age had a significant effect on both clinical pregnancy and live birth. Conclusion:For those DOR patients who had undergone ovarian endometriosis cystectomy, the prolonged GnRHagonist protocol may achieve better clinical IVF-ET outcomes, but there were no significant differences from the other groups. The GnRH-antagonist protocol may reduce the cost and time of drug treatment. Age should be considered for its influence on pregnancy outcome. However, a larger sample size may be needed for further study.

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Section: Discussionmentioning

confidence: 99%

Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study

et al. 2020

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“…when treating endometriosis. A multidisciplinary approach including gynaecologists, fertility specialists, sexologists and psychotherapists should be offered to provide best possible support (La Rosa et al, 2019). Future studies should address effects of such support on sexuality in couples dealing with endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Qualitative and quantitative aspects of sex life in the context of endometriosis: a multicentre case control study

Bernays

Schwartz

Geraedts

et al. 2020

Reproductive BioMedicine Online

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Highlights  Women with endometriosis have less often sexual intercourse and petting than control women  Women with endometriosis desire higher levels of sexual activity then their current level  As to expect dyspareunia is negatively correlated with sexual activity  Potentially pain-free sexual options are used to a limited degree and consequently represent a valuable resource to augment sexual activity

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“…For this reason, endometriosis is considered a disabling condition that may significantly compromise social relationships, sexuality, and mental health. [ 1 – 3 ] Approximately 10% of women of reproductive ages were affected by endometriosis and 30% to 50% of them suffer from infertility. Despite its negative impact on the quality of patients’ life, many issues related to endometriosis remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Current biomarkers for the detection of endometriosis

Tian

Chang

Zhao

et al. 2020

Chinese Medical Journal

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A clinically reliable non-invasive test for endometriosis is expected to reduce the diagnostic delay. Although varieties of biomarkers have been investigated for decades, and cancer antigen-125, cancer antigen-199, interleukin-6, and urocortin were the most studied ones among hundreds of biomarkers, no clinically reliable biomarkers have been confirmed so far. Some emerging technologies including “omics” technologies, molecular imaging techniques, and microRNAs are promising in solving these challenges, but their utility to detect endometriosis has yet to be verified. New combinations of researched indicators or other non-invasive methods and further exploration of the emerging technologies may be new targets and future research hotspots for non-invasive diagnosis of endometriosis. In conclusion, researches of biomarkers for the detection of endometriosis are still ongoing and may benefit from novel molecular biology, bioinformatics methods and a combination of more diverse monitoring methods. Though it will be a daunting task, the identification of a specific set of diagnostic biomarkers will undoubtedly improve the status of endometriosis.

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An overview on the relationship between endometriosis and infertility: the impact on sexuality and psychological well-being

Cited by 61 publications

References 51 publications

Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study

Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study

Qualitative and quantitative aspects of sex life in the context of endometriosis: a multicentre case control study

Current biomarkers for the detection of endometriosis

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