An Overview on the Synthesis and Biological Studies of Some Seven Membered Heterocyclic Systems

Ахметова, В. Р.; Khabibullina, G. R.; Ибрагимов, А. Г.

doi:10.1007/978-981-19-0832-3_5

Cited by 2 publications

(2 citation statements)

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“…Seven‐membered N ‐heterocyclic compounds like benzazepines are widely used in drug discovery due to their bioactive nature [41] . In 2022, the Shi group developed a methodology for the synthesis of these types of motifs from highly strained ring systems like alkylidenecyclopropanes 119 via a cascade ring opening pathway (Scheme 23).…”

Section: C(sp2)–c(sp3) Bond Formationmentioning

confidence: 99%

“…The proposed mechanism for this reaction begins with a SET between the Cu(I) catalyst and oxidant cumO Seven-membered N-heterocyclic compounds like benzazepines are widely used in drug discovery due to their bioactive nature. [41] In 2022, the Shi group developed a methodology for the synthesis of these types of motifs from highly strained ring systems like alkylidenecyclopropanes 119 via a cascade ring opening pathway (Scheme 23). [42] This intramolecular transformation mediated by an XAT chain propagation process afforded products 120 in moderate to good yields.…”

Section: C(sp 2 )-C(sp 3 ) Bond Formationmentioning

confidence: 99%

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An Overview of α‐Aminoalkyl Radical Mediated Halogen‐Atom Transfer

2023

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The merging of photocatalysis with halogen‐atom transfer (XAT) processes has proven to be a versatile tool for the generation of carbon‐centered radicals in organic synthesis. XAT processes are unique in that they generate radicals without requiring the use of strong reductants necessary for the traditional single electron transfer (SET) activation of halides. Pathways to achieve XAT in synthetic applications can be categorized into three major sections: i) heteroatom‐based activators, ii) metal‐based activators, and iii) carbon‐based activators among which α‐aminoalkyl radicals have taken the center stage. Access to these α‐aminoalkyl radicals as XAT reagents has gained significant attention in the past few years due to the robustness of the reactions, the simplicity of the reagents required, and the broadness of their applications. Generation of these α‐aminoalkyl radicals is simply achieved through the single electron oxidation of tertiary amines, which after deprotonation at the α‐position generates the α‐aminoalkyl radicals. Due to the wide scope of tertiary amines available and the tunable nucleophilicity of α‐aminoalkyl radical formed, this strategy has become an attractive alternative to heteroatom/metal‐based radicals for XAT. In this minireview, we focus our attention on recent (2020‐2023) developments and uses of this robust technology to mediate XAT processes.

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Section: C(sp2)–c(sp3) Bond Formationmentioning

confidence: 99%

Section: C(sp 2 )-C(sp 3 ) Bond Formationmentioning

confidence: 99%